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Depade (naltrexone) Disease Interactions

There is 1 disease interaction with Depade (naltrexone):


Opiate antagonists (Includes Depade) ↔ hepatic/renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction, Liver Disease

Opiate antagonists are metabolized by the liver (naltrexone to an active metabolite) and eliminated by the kidney. Hepatic and renal impairment may reduce the metabolism and clearance of opiate antagonists. Dosage adjustment for single dose administration is not necessary, however, repeated doses in patients with hepatic and/or renal dysfunction may require adjustment.


  1. "Product Information. Revex (nalmefene)." Ohmeda Pharmaceutical Products Division, Liberty Corner, NJ.
  2. "Product Information. Narcan (naloxone)." DuPont Pharmaceuticals, Wilmington, DE.

Depade (naltrexone) drug interactions

There are 557 drug interactions with Depade (naltrexone)

Depade (naltrexone) alcohol/food interactions

There is 1 alcohol/food interaction with Depade (naltrexone)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.