Methysergide maleate Disease Interactions
There is 1 disease interaction with methysergide maleate.
Ergot alkaloids (applies to methysergide maleate) vasospastic reactions
Major Potential Hazard, High plausibility. Applicable conditions: Sepsis, Shock, Hypertension, Peripheral Arterial Disease, Renal Dysfunction, Ischemic Heart Disease, Liver Disease
The use of ergot alkaloids is contraindicated in patients with conditions predisposing them to vasospastic reactions, including, ischemic heart disease (angina, history of myocardial infarction, silent ischemia), peripheral vascular disease, sepsis, shock, vascular surgery, uncontrolled hypertension, and severely impaired hepatic or renal function. The vasoconstriction produced be ergot alkaloids may exacerbate these conditions. Ergot alkaloids may cause vasospastic reactions other than coronary artery vasospasm such as peripheral vascular reactions, and colonic ischemia, causing muscle pains, numbness, coldness, pallor, and cyanosis of the digits. In patients with compromised circulation, persistent vasospasm may result in gangrene or death. Nitroprusside and heparin have been used to treat ergotamine- induced severe vasoconstriction.
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Methysergide maleate drug interactions
There are 283 drug interactions with methysergide maleate.
Methysergide maleate alcohol/food interactions
There are 3 alcohol/food interactions with methysergide maleate.
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- Drug class: antimigraine agents
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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