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Methysergide Maleate Dosage

Applies to the following strengths: 2 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Cluster Headache

For the prophylaxis of cluster headaches: 4 to 8 mg daily orally in divided doses with meals.

Usual Adult Dose for Migraine

For the prophylaxis of migraine headaches: 4 to 8 mg daily orally in divided doses with meals.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Data not available

Other Comments

There must be a drug-free interval of 3 to 4 weeks after every 6 month course of treatment.

If after a 3 week trial period, efficacy has not been demonstrated, continued administration is unlikely to be beneficial.

The protective effect of methysergide reportedly develops in 1 to 2 days and persists 1 to 2 days after the drug is discontinued.

Patients who take ergotamine for extended periods of time may become dependent on it and require progressively increasing doses for relief of vascular headaches and for prevention of dysphoria effects which follow withdrawal.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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