Ketoconazole Disease Interactions
There are 4 disease interactions with ketoconazole:
Ketoconazole (Includes Ketoconazole) ↔ Hepatotoxicity
Severe Potential Hazard, High plausibility
Applies to: Liver Disease
Serious hepatotoxicity including cases with a fatal outcome or requiring liver transplant have been reported. Some patients had no obvious risk factors for liver disease. Liver function tests should be performed prior to initiation of therapy and regularly during treatment in patients receiving prolonged therapy with ketoconazole, particularly those with a current or past history of liver disease. Therapy should be withdrawn if persistent elevations or worsening of liver enzyme levels occur, or if the abnormalities are accompanied by symptoms of possible liver injury. Since ketoconazole is primarily metabolized by the liver, empirically reducing the dosage may also be appropriate in patients with existing liver disease. The use of oral ketoconazole tablets is contraindicated in patients with acute or chronic liver disease.
- "Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ.
- Stricker BH, Blok AP, Bronkhorst FB, et al "Ketoconazole-associated hepatic injury: a clinicopathological study of 55 cases." J Hepatol 3 (1986): 399-406
- Bercoff E, Bernuau J, Degott C, et al "Ketoconazole-induced fulminant hepatitis." Gut 26 (1985): 636-8
Azole Antifungals (Includes Ketoconazole) ↔ Qt Prolongation
Moderate Potential Hazard, Moderate plausibility
Applies to: Long QT Syndrome, Arrhythmias
Most of the azole antifungals have been associated with prolongation of the QT interval. There have been postmarketing rare reports of QT prolongation, and torsade de pointes usually involving patients with risk factors such as structural heart disease, electrolyte abnormalities, and concomitant medications. These drugs should be administered with caution to patients with potentially proarrhythmic conditions. Concomitant use with other medications that have potential to increase the risk of cardiotoxicity should be avoided.
Ketoconazole (Includes Ketoconazole) ↔ Achlorhydria
Moderate Potential Hazard, High plausibility
Applies to: Achlorhydria
Nizoral (brand of ketoconazole) tablets require acidity for proper dissolution and absorption. Therefore, the drug may not be effective in patients with achlorhydria. Taking the medication with an acidic beverage such as orange or cranberry juice may help, but an alternative antifungal agent should be considered.
- Lake-Bakaar G, Tom W, Lake-Bakaar D, et al "Gastropathy and ketoconazole malabsorption in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 109 (1988): 471-3
- Daneshmend TK, Warnock DW, Ene MD, et al "Influence of food on the pharmacokinetics of ketoconazole." Antimicrob Agents Chemother 25 (1984): 1-3
- Mannisto PT, Mantyla R, Nykanen S, et al "Impairing effect of food on ketoconazole absorption." Antimicrob Agents Chemother 21 (1982): 730-3
Ketoconazole (Includes Ketoconazole) ↔ Adrenal Insufficiency
Moderate Potential Hazard, Moderate plausibility
Applies to: Adrenal Insufficiency
Ketoconazole tablets decrease adrenal corticosteroid secretion at doses of 400 mg and higher. Adrenal function should be monitored in patients with adrenal insufficiency or with borderline adrenal function and in patients with prolonged periods of stress due to major surgery, intensive care, etc.
ketoconazole drug Interactions
There are 745 drug interactions with ketoconazole
ketoconazole alcohol/food Interactions
There is 1 alcohol/food interaction with ketoconazole
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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