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Edoxaban Disease Interactions

There are 4 disease interactions with edoxaban:

Major

Factor Xa inhibitors (applies to edoxaban) bleeding

Major Potential Hazard, Moderate plausibility.

The use of factor Xa inhibitors is contraindicated in patients with active pathological bleeding. Its use increases the risk of bleeding and can cause serious or fatal bleeding. Caution is recommended when prescribing these agents to patients at increased risk of bleeding. When using these agents, the risk of thrombotic events should be weighed against the risk of bleeding.

Major

Factor Xa inhibitors (applies to edoxaban) hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

In general, the manufacturer recommends avoiding the use of factor Xa inhibitors in patients with moderate and severe hepatic impairment or with any hepatic disease associated with coagulopathy as drug exposure and bleeding risk may be increased.

Major

Factor Xa inhibitors (applies to edoxaban) valvular heart disease

Major Potential Hazard, Moderate plausibility. Applicable conditions: Prosthetic Heart Valves

The use of factor Xa inhibitors is not recommended in patients with prosthetic heart valves as no studies have been conducted for safety and efficacy.

Moderate

Edoxaban (applies to edoxaban) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Edoxaban is eliminated primarily as unchanged drug in the urine. Blood levels of edoxaban are increased in patients with renal dysfunction. The use of edoxaban is not recommended in patients with CrCl < 15 mL/min. It is recommended to reduce the dose to 30 mg once daily in these patients. The clearance of edoxaban is not significantly affected by hemodialysis. Care should be exercised when using this agent in patients with renal dysfunction.

Edoxaban drug interactions

There are 241 drug interactions with edoxaban

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.