Edoxaban Disease Interactions
There are 4 disease interactions with edoxaban:
Factor Xa inhibitors (applies to edoxaban) bleeding
Major Potential Hazard, Moderate plausibility.
The use of factor Xa inhibitors is contraindicated in patients with active pathological bleeding. Its use increases the risk of bleeding and can cause serious or fatal bleeding. Caution is recommended when prescribing these agents to patients at increased risk of bleeding. When using these agents, the risk of thrombotic events should be weighed against the risk of bleeding.
Factor Xa inhibitors (applies to edoxaban) hepatic impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
In general, the manufacturer recommends avoiding the use of factor Xa inhibitors in patients with moderate and severe hepatic impairment or with any hepatic disease associated with coagulopathy as drug exposure and bleeding risk may be increased.
Factor Xa inhibitors (applies to edoxaban) valvular heart disease
Major Potential Hazard, Moderate plausibility. Applicable conditions: Prosthetic Heart Valves
The use of factor Xa inhibitors is not recommended in patients with prosthetic heart valves as no studies have been conducted for safety and efficacy.
Edoxaban (applies to edoxaban) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Edoxaban is eliminated primarily as unchanged drug in the urine. Blood levels of edoxaban are increased in patients with renal dysfunction. The use of edoxaban is not recommended in patients with CrCl < 15 mL/min. It is recommended to reduce the dose to 30 mg once daily in these patients. The clearance of edoxaban is not significantly affected by hemodialysis. Care should be exercised when using this agent in patients with renal dysfunction.
Edoxaban drug interactions
There are 241 drug interactions with edoxaban
More about edoxaban
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
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- Drug class: factor Xa inhibitors
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|