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Prudoxin (doxepin topical) Disease Interactions

There are 2 disease interactions with Prudoxin (doxepin topical):

Moderate

Doxepin topical (applies to Prudoxin) anticholinergic effects

Moderate Potential Hazard, High plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension, Urinary Retention, Gastrointestinal Obstruction, Dementia

Doxepin possesses anticholinergic activity and is systemically absorbed when applied topically. Therapy with doxepin should be administered cautiously in patients with conditions adversely affected by anticholinergic activity, such as urinary retention, angle-closure glaucoma or elevated intraocular pressure, gastrointestinal obstructive disorders, or dementia.

References

  1. "Product Information. Zonalon (doxepin topical)." Bioglan Pharmaceutical Inc, Malvern, PA.
  2. Jones MI, Skaufle ML "Systemic adverse effects from topical doxepin cream." Ann Pharmacother 35 (2001): 505-6
Moderate

Doxepin topical (applies to Prudoxin) renal/hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease

Doxepin topical is systemically absorbed and metabolized by the liver to an active form. Parent drug and metabolites are eliminated by the kidney. Renal and hepatic impairment alter the metabolism and elimination of doxepin and/or its metabolites.

References

  1. Faulkner RD, Senekjian HO, Lee CS "Hemodialysis of doxepin and desmethyldoxepin in uremic patients." Artif Organs 8 (1984): 151-5
  2. Jones MI, Skaufle ML "Systemic adverse effects from topical doxepin cream." Ann Pharmacother 35 (2001): 505-6
  3. "Product Information. Zonalon (doxepin topical)." Bioglan Pharmaceutical Inc, Malvern, PA.
  4. Ziegler VE, Biggs JT, Wylie LT, Rosen SH, Hawf DJ, Coryell WH "Doxepin kinetics." Clin Pharmacol Ther 23 (1978): 573-9
View all 4 references

Prudoxin (doxepin topical) drug interactions

There are 528 drug interactions with Prudoxin (doxepin topical)

Prudoxin (doxepin topical) alcohol/food interactions

There is 1 alcohol/food interaction with Prudoxin (doxepin topical)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.