D.H.E. 45 (dihydroergotamine) Disease Interactions
There is 1 disease interaction with D.H.E. 45 (dihydroergotamine):
Ergot alkaloids (Includes D.H.E. 45) ↔ vasospastic reactions
Severe Potential Hazard, High plausibility. Applies to: Liver Disease, Shock, Peripheral Arterial Disease, Sepsis, Renal Dysfunction, Ischemic Heart Disease, Hypertension
The use of ergot alkaloids is contraindicated in patients with conditions predisposing them to vasospastic reactions, including, ischemic heart disease (angina, history of myocardial infarction, silent ischemia), peripheral vascular disease, sepsis, shock, vascular surgery, uncontrolled hypertension, and severely impaired hepatic or renal function. The vasoconstriction produced be ergot alkaloids may exacerbate these conditions. Ergot alkaloids may cause vasospastic reactions other than coronary artery vasospasm such as peripheral vascular reactions, and colonic ischemia, causing muscle pains, numbness, coldness, pallor, and cyanosis of the digits. In patients with compromised circulation, persistent vasospasm may result in gangrene or death. Nitroprusside and heparin have been used to treat ergotamine- induced severe vasoconstriction.
- "Product Information. Migranal (dihydroergotamine nasal)." Novartis Pharmaceuticals, East Hanover, NJ.
- "Product Information. D.H.E. 45 (dihydroergotamine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
D.H.E. 45 (dihydroergotamine) drug interactions
There are 645 drug interactions with D.H.E. 45 (dihydroergotamine)
D.H.E. 45 (dihydroergotamine) alcohol/food interactions
There are 3 alcohol/food interactions with D.H.E. 45 (dihydroergotamine)
More about D.H.E. 45 (dihydroergotamine)
- D.H.E. 45 Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- 8 Reviews
- Generic Availability
- Drug class: antimigraine agents
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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