Dextran 40 in 5% Dextrose Disease Interactions
There are 4 disease interactions with Dextran 40 in 5% Dextrose (dextran, low molecular weight).
Dextran (applies to Dextran 40 in 5% Dextrose) cardiac failure
Major Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease
Low molecular weight and high molecular weight dextran is contraindicated in patients with marked cardiac decompensation.
Dextran (applies to Dextran 40 in 5% Dextrose) hemostatic defects
Major Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect, Thrombocytopenia
The use of dextran is contraindicated in patients with marked hemostatic defects of all types (thrombocytopenia, hypofibrinogenemia, etc.) including those caused by drugs such as heparin, warfarin, etc.
Dextran (applies to Dextran 40 in 5% Dextrose) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Low molecular and high molecular weight dextran are contraindicated in patients with renal disease with severe oliguria or anuria.
Dextran (applies to Dextran 40 in 5% Dextrose) bleeding
Moderate Potential Hazard, Moderate plausibility.
Caution should be employed when using dextran (low and high molecular weight) in patients with active hemorrhage as the resulting increase in perfusion pressure and improved microcirculatory flow may result in additional blood loss.
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Dextran 40 in 5% Dextrose drug interactions
There are 34 drug interactions with Dextran 40 in 5% Dextrose (dextran, low molecular weight).
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- Drug class: plasma expanders
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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