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Dextran 40 in 0.9% Sodium Chloride Disease Interactions

There are 4 disease interactions with Dextran 40 in 0.9% Sodium Chloride (dextran, low molecular weight).

Major

Dextran (applies to Dextran 40 in 0.9% Sodium Chloride) cardiac failure

Major Potential Hazard, Moderate plausibility. Applicable conditions: Heart Disease

Low molecular weight and high molecular weight dextran is contraindicated in patients with marked cardiac decompensation.

Major

Dextran (applies to Dextran 40 in 0.9% Sodium Chloride) hemostatic defects

Major Potential Hazard, Moderate plausibility. Applicable conditions: Bleeding Associated with Coagulation Defect, Thrombocytopenia

The use of dextran is contraindicated in patients with marked hemostatic defects of all types (thrombocytopenia, hypofibrinogenemia, etc.) including those caused by drugs such as heparin, warfarin, etc.

Major

Dextran (applies to Dextran 40 in 0.9% Sodium Chloride) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Low molecular and high molecular weight dextran are contraindicated in patients with renal disease with severe oliguria or anuria.

Moderate

Dextran (applies to Dextran 40 in 0.9% Sodium Chloride) bleeding

Moderate Potential Hazard, Moderate plausibility.

Caution should be employed when using dextran (low and high molecular weight) in patients with active hemorrhage as the resulting increase in perfusion pressure and improved microcirculatory flow may result in additional blood loss.

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Dextran 40 in 0.9% Sodium Chloride drug interactions

There are 33 drug interactions with Dextran 40 in 0.9% Sodium Chloride (dextran, low molecular weight).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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