Dalfampridine Disease Interactions
There are 2 disease interactions with dalfampridine.
Dalfampridine (applies to dalfampridine) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Dalfampridine is contraindicated in patients with moderate or severe renal impairment (CrCl<=50 mL/min). Dalfampridine is eliminated through the kidneys primarily as unchanged drug and its clearance is decreased in patients with renal impairment and is significantly correlated with creatinine clearance.
Dalfampridine (applies to dalfampridine) seizures
Major Potential Hazard, Moderate plausibility.
Dalfampridine is contraindicated in patients with a history of seizures. Dalfampridine can cause seizures and it is recommended to permanently discontinue treatment in patients who have a seizure while on treatment.
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Dalfampridine drug interactions
There are 51 drug interactions with dalfampridine.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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