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Ampyra Disease Interactions

There are 2 disease interactions with Ampyra (dalfampridine).

Major

Dalfampridine (applies to Ampyra) renal impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Dalfampridine is contraindicated in patients with moderate or severe renal impairment (CrCl<=50 mL/min). Dalfampridine is eliminated through the kidneys primarily as unchanged drug and its clearance is decreased in patients with renal impairment and is significantly correlated with creatinine clearance.

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Major

Dalfampridine (applies to Ampyra) seizures

Major Potential Hazard, Moderate plausibility.

Dalfampridine is contraindicated in patients with a history of seizures. Dalfampridine can cause seizures and it is recommended to permanently discontinue treatment in patients who have a seizure while on treatment.

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Ampyra drug interactions

There are 49 drug interactions with Ampyra (dalfampridine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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