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Ampyra (dalfampridine) Disease Interactions

There are 2 disease interactions with Ampyra (dalfampridine):


Dalfampridine (Includes Ampyra) ↔ renal impairment

Severe Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

Dalfampridine is contraindicated in patients with moderate or severe renal impairment (CrCl<=50 mL/min). Dalfampridine is eliminated through the kidneys primarily as unchanged drug and its clearance is decreased in patients with renal impairment and is significantly correlated with creatinine clearance.


Dalfampridine (Includes Ampyra) ↔ seizures

Severe Potential Hazard, Moderate plausibility. Applies to: Seizures

Dalfampridine is contraindicated in patients with a history of seizures. Dalfampridine can cause seizures and it is recommended to permanently discontinue treatment in patients who have a seizure while on treatment.

Ampyra (dalfampridine) drug interactions

There are 59 drug interactions with Ampyra (dalfampridine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.