Dabigatran Disease Interactions
There are 3 disease interactions with dabigatran:
Dabigatran (Includes dabigatran) ↔ valvular heart disease
Major Potential Hazard, Moderate plausibility. Applies to: Prosthetic Heart Valves
The use of dabigatran for the prophylaxis of thromboembolic events in patients with atrial fibrillation in the setting of other forms of valvular heart disease, including the presence of a bioprosthetic heart valve has not been studied and it is not recommended. The use of dabigatran is contraindicated in patients with mechanical prosthetic valves.
Thrombin inhibitors (Includes dabigatran) ↔ active bleeding
Major Potential Hazard, High plausibility. Applies to: Bleeding, Coagulation Defect
The use of thrombin inhibitors is contraindicated in the presence of active major bleeding. Additionally, these drugs should be used with caution in patients with disease states associated with an increased risk of bleeding.
Dabigatran (Includes dabigatran) ↔ renal impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
The anticoagulant activity and half-life of dabigatran may increase in patients with renal impairment. It is recommended to decrease the dose in patients with severe renal impairment (CrCl 15-30 mL/min). No dose adjustment is recommended in patients with mild or moderate renal impairment. Dosing recommendations for patients with CrCl <15 mL/min or on dialysis has not been established. Care should be exercised when using this agent in patients with renal impairment or on dialysis.
Dabigatran drug interactions
There are 246 drug interactions with dabigatran
More about dabigatran
- Side Effects
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- Imprints, Shape & Color Data
- Drug Interactions
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- 86 Reviews
- Drug class: thrombin inhibitors
- FDA Alerts (4)
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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