Dabigatran Disease Interactions
There are 2 disease interactions with dabigatran:
Dabigatran (Includes Dabigatran) ↔ Valvular Heart Disease
Severe Potential Hazard, Moderate plausibility
Applies to: Valvular Heart Disease, Prosthetic Heart Valves
The use of dabigatran for the prophylaxis of thromboembolic events in patients with atrial fibrillation in the setting of other forms of valvular heart disease, including the presence of a bioprosthetic heart valve has not been studied and it is not recommended. The use of dabigatran is contraindicated in patients with mechanical prosthetic valves.
Thrombin Inhibitors (Includes Dabigatran) ↔ Active Bleeding
Severe Potential Hazard, High plausibility
Applies to: Bleeding, Coagulation Defect
The use of thrombin inhibitors is contraindicated in the presence of active major bleeding. Additionally, these drugs should be used with caution in patients with disease states associated with an increased risk of bleeding.
dabigatran drug Interactions
There are 382 drug interactions with dabigatran
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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