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Mitigare (colchicine) Disease Interactions

There are 2 disease interactions with Mitigare (colchicine):

Major

Colchicine (Includes Mitigare) ↔ Dic

Severe Potential Hazard, High plausibility

Applies to: Disseminated Intravascular Coagulation

Colchicine should be used with caution in patients with disseminated intravascular coagulation. Debilitated patients have an increased risk of developing colchicine toxicity.

References

  1. Vedia C, Mascort JJ, Carrasco I, Olive A "Colchicine and thrombopenia." Clin Exp Rheumatol 11 (1993): 458
  2. "Product Information. Colchicine (colchicine)." Lilly, Eli and Company, Indianapolis, IN.
Major

Colchicine (Includes Mitigare) ↔ Liver Disease

Severe Potential Hazard, High plausibility

Applies to: Liver Disease

The clearance of colchicine may be significantly reduced and plasma half-life prolonged in patients with chronic hepatic impairment compared to healthy subject. No pharmacokinetic data are available for patients with severe hepatic impairment (Child-Pugh C). Caution is recommended when prescribing colchicine to these patients.

References

  1. Warnes TW, Smith A, Lee FI, Haboubi NY, Johnson PJ, Hunt L "A controlled trial of colchicine in primary biliary cirrhosis. Trial design and preliminary report." J Hepatol 5 (1987): 1-7
  2. Kocak N, Yuce A, Gurakan F, Ozen H, Gogus S, Kale G, Caglar M "Colchicine in the treatment of hepatic fibrosis in children." Am J Gastroenterol 91 (1996): 179-80
  3. Stanley MW, Taurog JD, Snover DC "Fatal colchicine toxicity: report of a case." Clin Exp Rheumatol 2 (1984): 167-71
View all 7 references

Mitigare (colchicine) drug Interactions

There are 365 drug interactions with Mitigare (colchicine)

Mitigare (colchicine) alcohol/food Interactions

There is 1 alcohol/food interaction with Mitigare (colchicine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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