Onexton (benzoyl peroxide / clindamycin topical) Disease Interactions
There is 1 disease interaction with Onexton (benzoyl peroxide / clindamycin topical):
Topical Clindamycin (Includes Onexton) ↔ Colitis
Severe Potential Hazard, Moderate plausibility
Applies to: Colitis/Enteritis (Noninfectious)
Clindamycin may be systemically absorbed when applied to the skin or mucosal membranes. Pseudomembranous colitis has been reported with systemically as well as topically administered clindamycin and may range in severity from mild to life-threatening, with an onset of up to several weeks following cessation of therapy. The colitis is usually characterized by severe, persistent diarrhea and severe abdominal cramps, and may be associated with the passage of blood and mucus. Therapy with topical clindamycin should be administered cautiously in patients with a history of gastrointestinal diseases, particularly colitis. There is some evidence that pseudomembranous colitis, if it occurs, may run a more severe course in these patients and that it may be associated with flares in their underlying disease activity. Certain products may be contraindicated by the manufacturer, and prescribers are advised to consult the package labeling. Clindamycin should be discontinued if significant diarrhea occurs during therapy. Stool cultures for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically. A large bowel endoscopy may be considered to establish a definitive diagnosis in cases of severe diarrhea.
- Borglund E, Hagermark O, Nord CE "Impact of topical clindamycin and systemic tetracycline on the skin and colon microflora in patients with acne vulgaris." Scand J Infect Dis Suppl 43 (1984): 76-81
- Vikenes K, LundTonnesen S, Schreiner A "Clostridium difficile-associated diarrhea after short term vaginal administration of clindamycin." Am J Gastroenterol 94 (1999): 1969-70
- Voron DA "Systemic absorption of topical clindamycin." Arch Dermatol 114 (1978): 798
Onexton (benzoyl peroxide / clindamycin topical) drug Interactions
There are 18 drug interactions with Onexton (benzoyl peroxide / clindamycin topical)
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.