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Tebamide (benzocaine / trimethobenzamide) Disease Interactions

There are 4 disease interactions with Tebamide (benzocaine / trimethobenzamide):

Major

Trimethobenzamide (applies to Tebamide) Reye's syndrome

Major Potential Hazard, High plausibility.

The use of trimethobenzamide should be avoided in children and adolescents whose signs and symptoms suggest Reye's syndrome. The extrapyramidal symptoms which can occur secondary to trimethobenzamide use may confound the diagnosis of Reye's syndrome. In addition, drugs with hepatotoxic potential such as trimethobenzamide may adversely affect the course of Reye's syndrome.

References

  1. Holmes C, Flaherty RJ "Trimethobenzamide HCL (Tigan)-induced extrapyramidal dysfunction in a neonate." J Pediatr 89 (1976): 669-70
  2. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.
Moderate

Benzocaine (applies to Tebamide) methemoglobinemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.

References

  1. "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health, Summit, NJ.
  2. "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals, Rochester, NY.
Moderate

Trimethobenzamide (applies to Tebamide) parkinsonism

Moderate Potential Hazard, High plausibility.

The use of trimethobenzamide has been associated with pseudo- parkinsonian reactions including mask- like faces, drooling, cogwheel rigidity, and shuffling gait. Therapy with trimethobenzamide should be administered cautiously in patients with parkinsonism.

References

  1. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.
Moderate

Trimethobenzamide (applies to Tebamide) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Trimethobenzamide is mostly eliminated by the kidneys and a dosage adjustment should be considered in patients with reduced renal function (creatinine clearance <= 70 mL/min), including some elderly patients.

Tebamide (benzocaine / trimethobenzamide) drug interactions

There are 261 drug interactions with Tebamide (benzocaine / trimethobenzamide)

Tebamide (benzocaine / trimethobenzamide) alcohol/food interactions

There is 1 alcohol/food interaction with Tebamide (benzocaine / trimethobenzamide)

More about Tebamide (benzocaine / trimethobenzamide)

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.