Tebamide Pediatric Disease Interactions
There are 4 disease interactions with Tebamide Pediatric (benzocaine / trimethobenzamide).
Trimethobenzamide (applies to Tebamide Pediatric) Reye's syndrome
Major Potential Hazard, High plausibility.
The use of trimethobenzamide should be avoided in children and adolescents whose signs and symptoms suggest Reye's syndrome. The extrapyramidal symptoms which can occur secondary to trimethobenzamide use may confound the diagnosis of Reye's syndrome. In addition, drugs with hepatotoxic potential such as trimethobenzamide may adversely affect the course of Reye's syndrome.
References
- Holmes C, Flaherty RJ (1976) "Trimethobenzamide HCL (Tigan)-induced extrapyramidal dysfunction in a neonate." J Pediatr, 89, p. 669-70
- (2001) "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc
Benzocaine (applies to Tebamide Pediatric) methemoglobinemia
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency
Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.
References
- (2001) "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health
- (2001) "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals
Trimethobenzamide (applies to Tebamide Pediatric) parkinsonism
Moderate Potential Hazard, High plausibility.
The use of trimethobenzamide has been associated with pseudo- parkinsonian reactions including mask- like faces, drooling, cogwheel rigidity, and shuffling gait. Therapy with trimethobenzamide should be administered cautiously in patients with parkinsonism.
References
- (2001) "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc
Trimethobenzamide (applies to Tebamide Pediatric) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Trimethobenzamide is mostly eliminated by the kidneys and a dosage adjustment should be considered in patients with reduced renal function (creatinine clearance <= 70 mL/min), including some elderly patients.
References
- (2001) "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc
Tebamide Pediatric drug interactions
There are 280 drug interactions with Tebamide Pediatric (benzocaine / trimethobenzamide).
Tebamide Pediatric alcohol/food interactions
There is 1 alcohol/food interaction with Tebamide Pediatric (benzocaine / trimethobenzamide).
More about Tebamide Pediatric (benzocaine / trimethobenzamide)
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: anticholinergic antiemetics
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.