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Antipyrine / benzocaine / zinc acetate otic Disease Interactions

There are 2 disease interactions with antipyrine / benzocaine / zinc acetate otic:

Major

Otic agents (applies to antipyrine/benzocaine/zinc acetate otic) perforated tympanic membrane

Major Potential Hazard, High plausibility. Applicable conditions: Chronic Otitis Media, Chronic Otitis Media

The use of medications that are intended for the treatment of otitis externa or other conditions of the external ear canal should generally be avoided, or otherwise approached with caution, in patients with a perforated tympanic membrane due to the risk of toxicity from medication that may get into the middle ear. Caution is also advised in patients with longstanding, chronic otitis media because of the possibility of a perforated tympanic membrane in such patients.

References

  1. "Multum Information Services, Inc. Expert Review Panel"
  2. Behrman R, Kliegman R, Arvin A, Nelson W, eds. "Nelson Textbook of Pediatrics. 15th ed." Philadelphia, PA: W.B. Saunders Company (1996):
Moderate

Benzocaine (applies to antipyrine/benzocaine/zinc acetate otic) methemoglobinemia

Moderate Potential Hazard, Low plausibility. Applicable conditions: G-6-PD Deficiency

Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.

References

  1. "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health, Summit, NJ.
  2. "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals, Rochester, NY.

More about antipyrine / benzocaine / zinc acetate otic

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.