Arimidex (anastrozole) Disease Interactions
There are 4 disease interactions with Arimidex (anastrozole):
Anastrozole (applies to Arimidex) cardiovascular
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Ischemic Heart Disease
In studies of women with preexisting ischemic heart disease, an increased incidence of ischemic cardiovascular events was observed with the use of anastrozole. Caution should be exercised when prescribing anastrozole to these patients.
Anastrozole (applies to Arimidex) cholesterol
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Hyperlipidemia
During a clinical trial, more patients receiving anastrozole were reported to have elevated serum cholesterol compared to patients receiving tamoxifen (9% versus 3.5%, respectively). Caution should be taken when this agent is prescribed to these patients.
Anastrozole (applies to Arimidex) hepatic dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Anastrozole is extensively metabolized by the liver. Analysis of the pharmacokinetic disposition of anastrozole in patients with hepatic cirrhosis indicates that dosage adjustments of anastrozole are not necessary in patients with mild to moderate hepatic impairment. Clinical monitoring for toxicity associated with anastrozole therapy is recommended. Therapy with anastrozole should be administered cautiously in patients with severe hepatic impairment.
- "Product Information. Arimidex (anastrozole)." Zeneca Pharmaceuticals, Wilmington, DE.
- Lonning PE, Geisler J, Dowsett M "Pharmacological and clinical profile of anastrozole." Breast Cancer Res Treat 49 (1998): s53-7
Anastrozole (applies to Arimidex) osteoporosis
Moderate Potential Hazard, Moderate plausibility.
Results from the clinical trial bone substudy at 12 and 24 months demonstrated that patients receiving anastrozole had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Caution should exercise when prescribing this agent to patients with a risk of fractures, such as the elderly and patients with osteoporosis. Consider bone mineral density monitoring in patients treated with anastrozole.
Arimidex (anastrozole) drug interactions
There are 18 drug interactions with Arimidex (anastrozole)
Arimidex (anastrozole) alcohol/food interactions
There is 1 alcohol/food interaction with Arimidex (anastrozole)
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- Drug class: aromatase inhibitors
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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