Acamprosate Disease Interactions
There are 2 disease interactions with acamprosate:
Acamprosate (applies to acamprosate) renal impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The use of acamprosate is contraindicated in patients with severe renal impairment (creatinine clearance of =< 30 mL/min). A dose reduction is recommended in patients with moderate renal impairment.
Acamprosate (applies to acamprosate) depression
Moderate Potential Hazard, Moderate plausibility.
Alcohol-dependent patients, including those patients being treated with acamprosate, should be monitored for the development of symptoms of depression or suicidal thinking. It is recommended to monitor patients being treated with acamprosate for worsening or the emergence of symptoms of depression or suicidality. Care should be exercised when using this agent in patients with depression.
Acamprosate alcohol/food interactions
There is 1 alcohol/food interaction with acamprosate
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- Drug class: drugs used in alcohol dependence
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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