Generic Name: streptokinase (strep-toe-KYE-nase)
Medically reviewed by Drugs.com. Last updated on June 22, 2020.
Commonly used brand name(s)
In the U.S.
Pharmacologic Class: Tissue Plasminogen Activator
Uses for streptokinase
Streptokinase is used to dissolve blood clots that have formed in the blood vessels. It is used immediately after symptoms of a heart attack occur to improve patient survival. Streptokinase may also be used to treat blood clots in the lungs (pulmonary embolism) and in the legs (deep venous thrombosis) .
Streptokinase is also used to dissolve blood clots in tubes (catheters) that are inserted in blood vessels .
Streptokinase is available only with your doctor's prescription .
Before using streptokinase
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For streptokinase, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to streptokinase or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of streptokinase in the pediatric population. Safety and efficacy have not been established .
No information is available on the relationship of age to the effects of streptokinase in geriatric patients .
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving streptokinase, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using streptokinase with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using streptokinase with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alteplase, Recombinant
- Dabigatran Etexilate
- Pentosan Polysulfate Sodium
- Protein C
- Reteplase, Recombinant
Using streptokinase with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other medical problems
The presence of other medical problems may affect the use of streptokinase. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding problems or a history of bleeding in any part of the body or
- Blood clotting disorder, uncontrolled or
- Brain disease or tumor or
- High blood pressure, uncontrolled or
- Stroke, recent (within two months) or
- Surgery or injury to the brain or spine, recent (within two months)—Streptokinase should NOT be used in these conditions .
- Catheter (tube) infection or
- Diabetes mellitus, uncontrolled or
- Eye problems from diabetes (e.g., hemorrhagic retinopathy) or high blood pressure or
- Heart disease or infections (e.g., mitral stenosis or endocarditis) or
- Injections into a blood vessel or
- Kidney disease, severe or
- Liver disease, severe or
- Lung disease (e.g., tuberculosis or severe bronchitis) or
- Pancreatitis or
- Placement of any tube into the body or
- Surgery or injury of any kind, major and recent—The chance of serious bleeding may be increased .
- Heart rhythm problems or
- Hypotension—These conditions may get worse .
- Streptococcal infection, recent (within 6 months) (e.g., sore throat, rheumatic fever)—Streptokinase may not be effective .
Proper use of streptokinase
A doctor or other trained health professional will give you streptokinase. Streptokinase is given through a needle or tube placed into one of your blood vessels .
Precautions while using streptokinase
Streptokinase can cause bleeding that usually is not serious. However, serious bleeding may occur in some people. To help prevent serious bleeding, carefully follow any instructions given by your doctor. Move around as little as possible, and do not get out of bed on your own, unless your doctor tells you it is all right to do so.
Watch for any bleeding or oozing on your skin, such as around the place of injection or where blood was drawn from your arm. Also, check for blood in your urine or bowel movements. If you have any bleeding or injuries, tell your doctor or nurse right away .
Streptokinase side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- unusual tiredness or weakness
- Blood in stool
- blood in urine
- nose bleeds
- red or purple spots on skin
- unusual bruising
- vomiting blood
- Abdominal pain or swelling
- back pain or backaches
- black, tarry stools
- burning, itching, redness, or soreness of skin
- cloudy urine
- cold clammy skin
- coughing up blood
- difficulty with breathing
- difficulty with swallowing
- fast heartbeat
- fast, weak pulse
- feeling of warmth
- greatly decreased frequency of urination or amount of urine
- hives or welts
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- muscle or bone pain
- nausea and vomiting
- noisy breathing
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- redness of the face, neck, arms, and occasionally, upper chest
- shortness of breath
- skin rash
- tightness in chest
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
More about streptokinase
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- 2 Reviews
- Drug class: thrombolytics
- Other brands
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.