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Pegfilgrastim-jmdb (Subcutaneous)

Generic Name: pegfilgrastim (peg-fil-GRA-stim - jmdb)

Medically reviewed by Drugs.com. Last updated on Nov 4, 2020.

Commonly used brand name(s)

In the U.S.

  • Fulphila

Available Dosage Forms:

  • Solution

Therapeutic Class: Hematopoietic

Pharmacologic Class: Pegfilgrastim

Uses for pegfilgrastim-jmdb

Pegfilgrastim-jmdb injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Pegfilgrastim-jmdb helps the bone marrow to make new white blood cells.

When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Pegfilgrastim-jmdb is used to reduce the risk of infection while you are being treated with cancer medicines.

Pegfilgrastim-jmdb is available only with your doctor's prescription.

Before using pegfilgrastim-jmdb

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pegfilgrastim-jmdb, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pegfilgrastim-jmdb or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of pegfilgrastim-jmdb injection in the pediatric population.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pegfilgrastim-jmdb in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of pegfilgrastim-jmdb. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bone marrow cancer or other bone marrow problems or
  • Glomerulonephritis (kidney disease) or
  • Leukocytosis (high white blood cell count) or
  • Lung disease or breathing problems or
  • Sickle cell disease (red blood cell disease)—Use with caution. May make these conditions worse.

Proper use of pegfilgrastim-jmdb

A nurse or other trained health professional may give you pegfilgrastim-jmdb. It is given as a shot under the skin of your upper arm, upper outer buttock, stomach, or thigh.

You may be taught how to give pegfilgrastim-jmdb at home. Make sure you understand all of the instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

Pegfilgrastim-jmdb comes with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions about:

  • How to prepare the injection.
  • The proper use of disposable syringes.
  • How to give the injection.
  • How long the injection can be stored at home.

Allow the medicine to warm to room temperature for 30 minutes before you inject it. If the medicine in the prefilled syringe has changed color, looks cloudy, or if you see particles in it, do not use it. Do not shake.

Use the syringe only once. Do not save leftover medicine.

Dosing

The dose of pegfilgrastim-jmdb will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of pegfilgrastim-jmdb. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injectable dosage form (solution):
    • To increase white blood cell count:
      • Adults—6 milligrams (mg) as a single injection under the skin once every cancer treatment cycle.
      • Children weighing less than 45 kilograms (kg)—Dose is based on body weight and must be determined by your doctor.
        • Weighing 31 kg to 44 kg—4 milligrams (mg) as a single injection under the skin once every cancer treatment cycle.
        • Weighing 21 kg to 30 kg—2.5 mg as a single injection under the skin once every cancer treatment cycle.
        • Weighing 10 kg to 20 kg—1.5 mg as a single injection under the skin once every cancer treatment cycle.
        • Weighing less than 10 kg—0.1 mg per kg body weight as a single injection under the skin once every cancer treatment cycle.

Missed dose

Pegfilgrastim-jmdb needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Keep pegfilgrastim-jmdb in its original carton. Throw away any medicine stored at room temperature for more than 72 hours. If frozen, thaw it in the refrigerator before using. Throw away any medicine if it has been frozen more than once.

Throw away used needles in a hard, closed container where the needles cannot poke through. Keep this container away from children and pets.

Precautions while using pegfilgrastim-jmdb

It is very important that your doctor check you or your child's progress at regular visits to make sure that pegfilgrastim-jmdb is working properly. Blood and urine tests may be needed to check for unwanted effects.

If you or your child have left upper stomach pain or shoulder pain, contact your doctor right away. This could be a symptom of a serious side effect with the spleen.

Check with your doctor right away at the first sign of any infection, such as fever, chills, cough, sore throat, or redness, swelling, or pain around a cut or sore.

Check with your doctor right away if you or your child develop a fever, chest pain or tightness, fast breathing, or trouble breathing. These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS).

Pegfilgrastim-jmdb may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash, itching, swelling of the face, tongue, or throat, trouble breathing, or chest pain after you receive the medicine.

You should not use pegfilgrastim-jmdb for 14 days before and up to 24 hours after you receive cancer medicines.

Pegfilgrastim-jmdb may cause kidney problems. Call your doctor right away if you or your child has swelling in the face or ankles, blood in the urine, or a decrease in how much or how often you urinate.

Check with your doctor right away if you or your child has black or tarry stools, bleeding gums, blood in the urine or stools, pinpoint red spots on the skin, or unusual bleeding or bruising after receiving pegfilgrastim-jmdb.

Pegfilgrastim-jmdb may cause a condition called capillary leak syndrome. It can cause fluid to leak from the blood vessels into your body's tissues. Call your doctor right away if you have swelling or puffiness and are urinating less often, trouble breathing, feeling of fullness, dizziness, or feeling faint.

Pegfilgrastim-jmdb may cause aortitis (inflammation of the aorta, the largest artery in the body). Check with your doctor right away if you have fever, stomach pain, unusual tiredness or weakness, or back pain.

Make sure any doctor or dentist who treats you knows that you are using pegfilgrastim-jmdb. Pegfilgrastim-jmdb may affect the results of certain medical tests (eg, bone tests).

Pegfilgrastim-jmdb side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

  • Chills
  • cough
  • eye pain
  • fever
  • general feeling of illness
  • headache
  • sore throat
  • unusual tiredness

Incidence not known

  • Back pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bloody or cloudy urine
  • blue lips, fingernails, or skin
  • chest pain
  • decrease or increase in the amount of urine
  • difficult or fast breathing
  • dry, red, hot, or irritated skin
  • fainting or lightheadedness
  • fast heartbeat
  • feeling of fullness
  • fever sores or blisters on the skin
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • nausea
  • pain spreading to the left shoulder
  • redness of the skin
  • stomach pain
  • swelling of the eyelids, face, lips, hands, or feet
  • troubled breathing or swallowing
  • weight gain

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Bone pain
  • chest pain or tightness
  • difficult or labored breathing
  • swelling

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Arm or leg pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.