Tamoxifen Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tamoxifen	Verzenio (abemaciclib)	Pembrolizumab	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tamoxifen	Verzenio (abemaciclib)	Pembrolizumab	Enter another drug to compare
Prescription only Prescribed for Breast Cancer - Adjuvant, Breast Cancer - Metastatic, Breast Cancer, Breast Cancer - Male, Breast Cancer - Palliative, Breast Cancer - Prevention, McCune-Albright Syndrome, Precocious... View more	Prescription only Verzenio (abemaciclib) is a targeted treatment that helps to reduce the growth and spread of cancer cells in the body. It may be used to treat HR+ HER2-, node-positive, early breast cancer at high... View more	Prescription only Prescribed for Bladder Cancer, Cervical Cancer, Breast Cancer, Biliary Tract Tumor, Colorectal Cancer, Endometrial Cancer, Esophageal Carcinoma, Gastric Cancer, Head and Neck Cancer, Hepatocellular... View more	Related suggestions Breast Cancer Anastrozole Letrozole Arimidex Exemestane Keytruda Abemaciclib Popular comparisons Tamoxifen vs anastrozole Tamoxifen vs exemestane Tamoxifen vs Arimidex Tamoxifen vs Evista Tamoxifen vs Aromasin Tamoxifen vs Faslodex
More about Tamoxifen	More about Verzenio (abemaciclib)	More about Pembrolizumab
Ratings & Reviews
Tamoxifen has an average rating of 5.5 out of 10 from a total of 96 ratings on Drugs.com. 31% of reviewers reported a positive effect, while 29% reported a negative effect.	Verzenio has an average rating of 8.1 out of 10 from a total of 26 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 4% reported a negative effect.	Pembrolizumab has an average rating of 5.1 out of 10 from a total of 265 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 47% reported a negative effect.
View all 96 reviews	View all 26 reviews	View all 265 reviews
Drug Class
Hormones/antineoplastics Selective estrogen receptor modulators	CDK 4/6 inhibitors	Anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)
Side Effects
Tamoxifen side effects	Verzenio side effects	Pembrolizumab side effects
Generic Availability
Lower cost generic	No lower cost generic approved	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card	Get free Discount Card

Dosage Forms Available
Oral tablet	N/A	N/A
Brand Names
Soltamox	N/A	Keytruda
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.
231 hours	24.8 hours	624 hours
CSA Schedule ** View glossary of terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
D Category D Positive evidence of risk See the full pregnancy warnings document.	Summary unavailable. See the full pregnancy warnings document.	D Category D Positive evidence of risk See the full pregnancy warnings document.
Drug Interactions
A total of 448 drugs are known to interact with Tamoxifen: 133 major drug interactions (496 brand and generic names) 304 moderate drug interactions (996 brand and generic names) 11 minor drug interactions (29 brand and generic names)	A total of 343 drugs are known to interact with Verzenio: 109 major drug interactions (314 brand and generic names) 227 moderate drug interactions (669 brand and generic names) 7 minor drug interactions (21 brand and generic names)	A total of 402 drugs are known to interact with Pembrolizumab: 3 major drug interactions (6 brand and generic names) 399 moderate drug interactions (1092 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Talk to your doctor before using tamoxifen with soy products. There is some evidence that... View more	Grapefruit juice can increase the blood levels of abemaciclib. This may increase side effects such... View more	No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
DVT/pulmonary embolism Endometrial dysplasia Hepatic dysfunction Myelosuppression Visual disturbances	Hepatic dysfunction Diarrhea ILD Neutropenia VTE Lung toxicity	Immune system disorder HSCT Myasthenia gravis Organ transplant Colitis Hepatic impairment Multiple myeloma Pneumonitis Thyroid disease
First Approval Date
December 30, 1977	September 28, 2017	N/A
WADA Class View World Anti-Doping Agency classifications.
S4 - Hormone and Metabolic Modulators	N/A	N/A
More Information
Side effects Pregnancy warnings Breastfeeding warnings Dosage information Drug images Drug interactions Support group Pricing and coupons En Español	Side effects Pregnancy warnings Breastfeeding warnings Dosage information Drug images Drug interactions Support group Pricing and coupons En Español	Side effects Pregnancy warnings Breastfeeding warnings Dosage information Drug interactions Support group En Español
Patient resources
Tamoxifen uses	Verzenio uses	Pembrolizumab uses
Professional Resources
Monograph (AHFS) Prescribing information	Prescribing information	Monograph (AHFS) Prescribing information
Related Treatment Guide
Breast Cancer - Adjuvant Breast Cancer - Metastatic Breast Cancer Breast Cancer - Male Breast Cancer - Palliative Breast Cancer - Prevention McCune-Albright Syndrome Precocious Puberty show all	Breast Cancer	Bladder Cancer Cervical Cancer Breast Cancer Biliary Tract Tumor Colorectal Cancer Endometrial Cancer Esophageal Carcinoma Gastric Cancer Head and Neck Cancer Hepatocellular Carcinoma Hodgkin's Lymphoma Malignant Pleural Mesothelioma Melanoma Melanoma - Metastatic Merkel Cell Carcinoma Non Small Cell Lung Cancer Ovarian Cancer Primary Mediastinal Large B-cell Lymphoma Renal Cell Carcinoma Solid Tumors Squamous Cell Carcinoma Urothelial Carcinoma show all

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Tamoxifen Alternatives Compared

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