Comparing Prolia vs Actonel
Prolia | Actonel |
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Prolia (denosumab) | Actonel (risedronate) |
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Prescription only
Prolia is an injection that can be self-administered once every six months for the treatment of osteoporosis. It has been associated with an increased risk of fractures on discontinuation and... View more |
Prescription only
Actonel helps to reduce the risk of fracture in people with osteoporosis and some other bone conditions. Dosage instructions, including remaining upright for at least 30 minutes and taking with a... View more |
Related suggestions |
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More about Prolia (denosumab) | More about Actonel (risedronate) | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Prolia has an average rating of 2.7 out of 10 from a total of 362 ratings on Drugs.com. 15% of reviewers reported a positive effect, while 78% reported a negative effect. |
Actonel has an average rating of 3.0 out of 10 from a total of 32 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 72% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: Prolia side effects in more detail. |
See also: Actonel side effects in more detail. |
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Generic Availability | |||||||||||||||||
N/A |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Prolia prices |
View all Actonel prices |
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Dosage Form(s) Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Other denosumab brands include: Jubbonti, Wyost, Xgeva | Other risedronate brands include: Atelvia | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
609.6 hours |
561 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 284 drugs are known to interact with Prolia:
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A total of 110 drugs are known to interact with Actonel:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
June 01, 2010 |
March 27, 1998 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.