Comparing Insulin Degludec vs Semglee

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Insulin degludec	Semglee (insulin glargine)	Enter another drug to compare

Insulin degludec

Semglee (insulin glargine)

Prescription only

Prescribed for Type 2 Diabetes, Diabetes - Type 1, Diabetes Mellitus. Insulin degludec may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Type 2 Diabetes, Diabetes - Type 1. Semglee may also be used for purposes not listed in this medication guide.

More about Insulin degludec

More about Semglee (insulin glargine)

Ratings & Reviews

Insulin degludec has an average rating of 4.4 out of 10 from a total of 156 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 55% reported a negative effect.

Semglee has an average rating of 3.7 out of 10 from a total of 13 ratings on Drugs.com. 15% of reviewers reported a positive effect, while 62% reported a negative effect.

View all 156 reviews

View all 13 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (11.5%)
Weight gain (11.5%)
Tiredness (7.7%)
Nausea (7.1%)
Bloating (6.4%)
Dizziness (6.4%)
Itching (6.4%)

View all Insulin degludec side effects

View all Semglee side effects

Drug Class

Insulin

Insulin

Generic Availability

Lower cost generic

N/A

Pricing and Coupons * Prices are without insurance

Quantity	10 mL
Strength	100 units/mL
Per unit^*	$13.66
Cost^*	$136.64

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Dosage Forms

Subcutaneous solution

Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

25 hours

24 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 393 drugs are known to interact with Insulin degludec:

15 major drug interactions (39 brand and generic names)
357 moderate drug interactions (1888 brand and generic names)
21 minor drug interactions (210 brand and generic names)

A total of 395 drugs are known to interact with Semglee:

15 major drug interactions (39 brand and generic names)
359 moderate drug interactions (1893 brand and generic names)
21 minor drug interactions (210 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood... View more

Disease Interactions

First Approval Date

N/A

June 11, 2020

WADA Class View classifications

N/A

More Information

Patient Resources

Insulin degludec uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Insulin Degludec vs Semglee

See also:

Rybelsus

Trulicity

Ozempic

Lantus

Tresiba

Levemir

Victoza

Novolog

Basaglar

Soliqua

Further information

Comparing Insulin Degludec vs Semglee

See also:

Further information

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