Comparing Aleve-D Sinus & Cold vs Sudafed PE Head Congestion + Flu Severe

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Aleve-D Sinus & Cold (naproxen / pseudoephedrine)	Sudafed PE Head Congestion + Flu Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Aleve-D Sinus & Cold (naproxen / pseudoephedrine)	Sudafed PE Head Congestion + Flu Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)	Enter another drug to compare
Over-the-counter Prescribed for Sinus Symptoms, Nasal Congestion, Pain/Fever. Aleve-D Sinus & Cold may also be used for purposes not listed in this medication guide.	Prescription and OTC Prescribed for Cold Symptoms, Influenza. Sudafed PE Head Congestion + Flu Severe may also be used for purposes not listed in this medication guide.
More about Aleve-D Sinus & Cold (naproxen / pseudoephedrine)	More about (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
Ratings & Reviews
Aleve-D Sinus & Cold has an average rating of 9.7 out of 10 from a total of 3 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.	Be the first to share your experience with this drug.
View all 3 reviews	Review this drug
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
View all Aleve-D Sinus & Cold side effects	View all Sudafed PE Head Congestion + Flu Severe side effects
Drug Class
Upper respiratory combinations	Upper respiratory combinations
Generic Availability
N/A	N/A
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral tablet, extended release	N/A
Brand Names
Other naproxen / pseudoephedrine brands include: Aleve-D Sinus & Headache, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain	Other acetaminophen / dextromethorphan / guaifenesin / phenylephrine brands include: Adult Cold, Flu & Sore Throat, Alka-Seltzer Plus Day Severe Cold+Flu Hot Drink Mix, Alka-Seltzer Plus Severe Cold, Mucus & Congestion, Alka-Seltzer Plus Severe Cough, Mucus & Congestion Liquid Gels, Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels, Cold & Cough PE Multi-Symptom, Cold Head Congestion, Cold Multi-Symptom Severe, ConRx Cold, Cough & Cold Relief, CounterAct Day, Decorel Forte Plus, Delsym Cough+ Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Children's FreeFrom Multi-Symptom Cold, Flu & Sore Throat, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Cold, Flu & Sore Throat Liquid Gels, Mucinex Fast-Max Day Time Severe Cold, Mucinex Fast-Max Severe Cold, Mucinex Fast-Max Severe Congestion & Cold, Mucinex Sinus-Max Pressure, Pain & Cough, Mucus Relief Complete, Mucus Relief Plus, Robitussin Severe Multi-Symptom Cough Cold + Flu, Rompe Pecho MAX, Sudafed PE Cold & Cough, Sudafed PE Pressure+Pain+Cold, Suphedrine PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold + Mucus Severe, Tylenol Cold Multi-Symptom Severe, Tylenol Cough & Severe Congestion Daytime, Vicks DayQuil Severe Cold & Flu View more
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
18 hours	N/A
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
N Category N Not classified See the full pregnancy warnings document.	N Category N Not classified See the full pregnancy warnings document.
Drug Interactions
A total of 627 drugs are known to interact with Aleve-D Sinus & Cold: 116 major drug interactions (501 brand and generic names) 489 moderate drug interactions (1992 brand and generic names) 22 minor drug interactions (168 brand and generic names)	A total of 625 drugs are known to interact with Sudafed PE Head Congestion + Flu Severe: 95 major drug interactions (291 brand and generic names) 514 moderate drug interactions (2305 brand and generic names) 16 minor drug interactions (57 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Ask your doctor before using naproxen together with alcohol. Do not drink alcohol while taking... View more	Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness... View more
Disease Interactions
Asthma Fluid retention GI toxicity Rash Renal toxicities Thrombosis Cardiovascular disease Sodium Anemia Hepatotoxicity Hyperkalemia Platelet aggregation inhibition GI narrowing PKU BPH Diabetes Glaucoma	Alcoholism Liver disease Cardiovascular disease PKU BPH Diabetes Glaucoma
First Approval Date
November 29, 1999	N/A
WADA Class View classifications
S6 - Stimulants	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Drug images	Side effects Drug interactions Dosage Pregnancy warnings Drug images
Patient Resources
Aleve-D Sinus & Cold uses	N/A
Professional Resources
N/A	N/A
Related Treatment Guide
Sinus Symptoms Nasal Congestion Pain/Fever	Cold Symptoms Influenza

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Aleve-D Sinus & Cold vs Sudafed PE Head Congestion + Flu Severe

See also:

Advil

Aleve

Ozempic

Afrin

Naprosyn

Excedrin

Sudafed Congestion

IBU

Ecotrin

Excedrin Migraine

Further information

Comparing Aleve-D Sinus & Cold vs Sudafed PE Head Congestion + Flu Severe

See also:

Further information

Compare Drugs