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User Reviews for Effexor XR to treat Depression

Effexor XR has an average rating of 6.5 out of 10 from a total of 328 ratings for the treatment of Depression. 55% of reviewers reported a positive experience, while 29% reported a negative experience.

Effexor XR rating summary

6.5/10 average rating

328 ratings from 348 user reviews.

Compare all 188 medications used in the treatment of Depression.

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Reviews for Effexor XR

Dora · Taken for 5 to 10 years · January 3, 2021

“In a few paragraphs, I can gladly proclaim this medication saved my life in sooo many ways! I had never felt content until I took Effexor. The grass was greener, the music was even more beautiful, I am now kind and patient again; I am simply happy! I don't need to constantly seek out pleasurable things to make life more exciting anymore. I’m not so emotionally vulnerable. For the first time in my life, I can READ! My ADHD has diminished 70% - 90%! Whether it be from ADHD, anhedonia or both, I can FINALLY enjoy the simple things in life. Lastly and miraculously, my IQ went up 15 - 20 points! My thought process is much more clear, and I LOOOVE reading and learning! My new-found curiosity fuels my joy for living and learning. I want to thank the people who created this drug. I am not only myself again, but I’m someone I never even knew I was capable of being!”

10 / 10
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Joe · Taken for 10 years or more · May 10, 2019

“I am a 43 years old man. I take Effexor XR 150mg since 2000 (yes I know it is long, but it is better than death). Ok, every 2-3 years I try to be "med free", "normal" and "out of the stigma", and each time it is the same. I crash. Hard. Each time, I play with my life. From the outside, I look successful, brilliant, intelligent, normal, etc. But I am sick as hell. Sick, but in treatment. I take care of me as I could and I really don't care about what people think about Venlafaxine now. I don't want to die. Believe me, noradrenaline and serotonin recapture is no garbage. You may need a little help for your brain. Refuse it if you like, but do something about depression before it will do something about you.”

10 / 10
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Alexandra · October 13, 2020

“Please remember to give Effexor XR a couple of months to work. The first month or even two are going to suck. Why? Remember that the chemicals in your brain are adjusting. We have a chemical imbalance. Be patient and kind to yourself. I was on Lexapro and it worked but I gained so much weight so I got off. Not a good idea. Never just go cold turkey! So, after speaking to my doctor he put me on Effexor and it has been such a blessing. I’m on 225mg for over 3 years and while I do have good and bad days because it’s not a miracle pill, you still have to fight the depression and anxiety but it helps you fight it. Stay strong! It works. Be patient. Don’t be scared.”

10 / 10
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Teppum · June 4, 2020

“I had severe anxiety in 2016, it was truly crippling. Along with panic attacks and thinking I was dying all the time, I experienced depersonalization/derealization every day. Effexor XR truly saved my life. I take my pills at night, and if I miss one dose, I know immediately the next day by how I feel. It’s a horrible feeling. I also described it as my head was skipping, but I see others describe it as brain zaps. That’s truly what it feels like. Besides that though, this medication changed everything for me.”

9 / 10
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Tawnya · Taken for 1 to 6 months · February 18, 2020

“I take 150mg time released effexor, I am dealing with a head injury for 6 months now. I have been on Effexor since. I have no side effects and it has really helped me with my anxiety, nervousness and depression. This medicine is such a life saver, I can go to work and be around people. I don’t know where I would be without this medication.”

10 / 10
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Ryan · January 23, 2020

“This drug is by far the best anti depression meds I’ve taken and I’ve been on since age 17 (now 34) of you miss a day you will be very emotional but other than that I haven’t noticed many bad side effects. My depression is great now and has been for year the only negative is my lack in sex drive and sleeping a lot. Not sure if that’s all the meds or just my lazy arse. Heard a lot of bad reviews but honestly I’ve been on it for 7 years and I think it’s great.”

9 / 10
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Spouse to a lost Vet · Taken for 2 to 5 years · August 4, 2021

“Please never allow anyone you love to take this drug! Effexor XR has been the worst experience for my husband the past 4 years! He has gone through so many changes, mentally he doesn’t know what is real anymore. What I mean is life, love, emotions, etc. Our marriage was the ideal marriage before he started taken it, but now it has crumbled! He has been to a mental facility twice on this drug, gone through so many personally changes, it’s unreal! Please do your research before taking this because coming off of it is a living nightmare! I know 2 people who committed suicide on this drug and Thank God I have not lost my husband on it!”

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Grateful · Taken for 5 to 10 years · February 4, 2020

“Everyone's different, for me this one's a LIFE SAVER! My depression began 15yrs ago. In 2014 I hit my lowest point. Previous dr had me on several meds that didn't mix well together. That whole year is a blur, I don't remember any of it except for the few grand mal seizures they caused. Eventually attempted suicide with one of the meds and ended up in a mental hospital twice within a month. My new psychiatrist took me off everything and started me on this, topped out at 150mg (which I am to this day, 6yrs later, still taking). I can't thank that psychiatrist and this miracle drug enough. Taking with Bupropion (Wellbutrin) and I'm not sure which one, but I believe one of them has got rid of my sex drive. I prefer no sex drive over that really dark place I was in. Also, if I miss taking them a couple of days in a row (again, not sure which one is causing it) I experience extreme vertigo.. not fun. Other than that, I have no other complaints just absolute gratefulness. LOVE IT!”

10 / 10
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Tol · August 29, 2015

“I have been on many anti-depressants over the years. I have had depression and anxiety since I was 21 years old, and am in my late 40's now. Other anti-depressants caused horrible cravings for sweets and carbs. Plus the medications didn't work that well for me. I have been on Effexor for 8 months, 150 mg. It works wonders for me. I actually like to be around people now. I go places etc... I have a life again, and noticed that I get excited about life. Also, I have lost weight on it. My cravings are gone, I feel full after a meal and full a lot longer after the meal. I am gaining back my energy. I am a woman who was so severely depressed, I couldn't even get out of my recliner, and didn't get dressed most days. What a difference!”

10 / 10
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hbaby · Taken for 1 to 6 months · June 20, 2013

“This medicine saved my life. I was at my wits end with anti-depressants and was ready to give up. My doctor finally prescribed me this after many failed medications, I am so glad she did. I honestly do not know where I would be without Effexor XR. Side effects were very mild compared to other anti-depressants I tried. I was drowsy for the first couple days, but it was tolerable. I highly recommend this for severe depression. I would also like to mention for people to realize there is light at the end of the tunnel and YOU WILL GET BETTER, and to never give up.”

10 / 10
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Cm · Taken for 1 to 6 months · August 16, 2019

“After 15 years of struggling with deep depression, pmdd, and post partum depression, 1 suicide attempt and 1 hospitalization, I have found the medicine Effexor that has worked for me. It's been a long road but now I'm at peace and living life to the fullest.”

9 / 10
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Interx · Taken for 1 to 6 months · April 14, 2021

“Have tried several different medications and every supplement including thyroid kelp etc since my three year battle with depression . Effexor didn’t do much for me for about 12-16 weeks I noticed a difference . First 8 weeks I had terrible insomnia I nearly stopped it . Having looked up treatment resistant depression I decided to try taking folate and 6 weeks later it’s the first time I’m feeling 90% myself again . I’m not sure if it’s the Effexor or the folate or both but if your not feeling like the meds are helping 100% I would consider adding folate . Don’t give up”

9 / 10
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Gamergirl4283 · Taken for 6 months to 1 year · April 15, 2020

“Effexor was by far the worst medication I have taken. If you miss even 1 dose within hours you are sick and having withdrawal symptoms. It took a good 6 months before the brain zaps stopped. Run away. It's terrible.”

1 / 10
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NLDIS · Taken for 6 months to 1 year · May 2, 2014

“I've tried many different SSRI's for depression (Zoloft, Wellbutrin, Prozac) and nothing worked. I was apprehensive to take the Effexor because of online reviews but I'm so glad I did! The only side effect I've had is tiredness the first few weeks but that has since subsided. I not only feel more energy but I actually can feel happiness. On the other medicines I just felt a numbness and lack of emotion but Effexor has made me feel like me again! This has been my miracle after years of mild-severe depression.”

10 / 10
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Crazy4Effexor · Taken for 2 to 5 years · February 11, 2020

“I originally started on the regular effexor when I was 16 after a suicide attempt while on prozac. This was literally a life saver for me! Switched to XR when it became available. I was on it for about 3 yrs, before deciding I no longer wanted to be anchored down by antidepressants. The withdrawals sucked...but didn't last long. I'm considering going back on it and am now 37 yrs old.”

10 / 10
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abdullahsoliman · Taken for 1 to 6 months · June 21, 2021

“I read a lot before taking this medicine because I heard about his horrible side effects and withdrawal symptoms but finally I decided to take it as I believe in all depression medications has side effects and withdrawal symptoms and for sure it won't be worst than depression . And if its approved by FDA and allowed in most of countries, so for sure it has also positive effects more than negative ones. After I took it I felt it change the depression after the first does! and now after 3 months of it, its the best medication I tried till now. But please know it has different effect form person to person. For me side effects was some nausea and night sweating and that was only for one day after that no side effects happened. So finally I tell you don't be afraid to take it - it is safe and strong antidepressant.”

10 / 10
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Mickey · Taken for 1 to 6 months · February 27, 2020

“I have only been taking Effexor for a little over 2 months and noticed that if I was even an hour late taking my daily dose I’d feel nauseous and anxious. I also began to notice that I was feeling nauseous anytime I didn’t have a full stomach, so weight gain was inevitable. I decided this drug was making my physical symptoms seriously distressing enough to outweigh any good it may be doing. I was shocked at how awful the withdrawal symptoms have been even though I was only on it for two months at a dose of 75mg. I’ve been experiencing nausea and “brain zaps” for two weeks now. My GP put me on Effexor, but after meeting a psychiatrist at a dinner function & casually asking her thoughts on Effexor she said she doesn’t prescribe it, its withdrawal is so awful. I’m glad I’m getting off it, but alarmed at how nasty the withdrawal is, can't imagine how bad withdrawal would be for those at a higher dosage and for much longer than my 2 months.”

1 / 10
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Effexor Queen · Taken for 10 years or more · October 17, 2018

“Been on Effexor 150 mg for 16 YEARS. Can't remember any side effects that weren't tolerable. I haven't had one problem in 16 years of taking it. I have had three clinical depression episode (about ten years apart) so I have to stay on an antidepressant for the rest of my life. I like to say....I'm a "quart low" on serotonin. Effexor has kept the level up. Happy patient!!”

10 / 10
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Nathan · October 21, 2019

“I have struggled with eating disorders (Anorexia and Binging) for about 4 years now. It started at 16 and slowly began to follow me into college. I’ve struggled with relationships and often find myself extremely depressed and more anxious than ever. I started Effexor about 2 weeks ago now and the first few days were much like the experiences listed on here. I have done MDMA before and it does feel like that for the first two days. However, after I got through that stage each day has been getting better. Colors seem brighter and my motivation has started to get better. Before, I had struggled with finding any interest in life and everything seems a little bit more open each day I wake up. I do have some very vivid dreams and find that during the night my depression gets a little worse, but it has slowly subsided and I’m able to push away thoughts that normal frustrate me. I’m excited to see how each day goes moving forward.”

10 / 10
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Ginnie · Taken for 1 to 6 months · March 10, 2020

“My neurologist prescribed me Effexor XR for nerve pain. I had a head injury from a car accident and have been suffering from facial nerve pain, neck injury, and depression. This drug has improved my quality of life. I highly recomend it for nerve pain. I started out taking 37.5mg for a month. Then, 75mg. The 75mg dose works for me. It took 6 weeks for me to feel the benefits.”

8 / 10
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jlady/Cincy · Taken for 1 to 2 years · April 22, 2019

“This (Effexor XR) is a GREAT drug! For those of you who have had a bad experience you need to have the swab test done by your Dr (covered by insurance) to find out what drugs work for you. Has been a lifesaver for me! I was switched by smart NP after taking Paxil for many years w many problems/after I took the mouth swab test & it showed Paxil was bad fit for me. I have zero side effects aside from a little weight loss which for me is awesome as I'm 57 & fit but had those nagging extra lbs. Extra lbs gone/mood lifted/don't dwell on stupid things. I'll be on it forever as I'm permanently low in serotonin & NEED the boost. Without it it I just lay in bed & don't want to do anything. Get the swab test done & if this shows up in the left column try it! Little adjustments with dosage is required - just start at 75mg which helps teenie bit & then go up...Its also cheap if you pay cash...GOOD LUCK!!!!!!”

10 / 10
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VIRIDIANA · April 11, 2014

“I BEEN TAKING EFFEXOR FOR 4weeks FINALLY I FEEL GOOD IT'S A MIRACLE I WAS SUFFERING REAL BAD DEPRESSION AND ANXIETY AND THOUGHTS OF GIVING UP ON LIFE. EFFEXOR WORKS, THIS IS THE BEST I FELT SINCE I WAS 23 NOW I'M 30 AND YES I FEEL VERY HAPPY TO KNOW I DIDN'T GIVE UP AND FINALLY FOUND A MIRACLE PILL AND IT'S ONLY BEEN A MONTH THANKS EFFEXOR SAVED MY LIFE THANK YOU.”

8 / 10
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nickname · Taken for 1 to 2 years · December 17, 2019

“This medication needs to be illegal. It did not help my depression, it caused significant weight gain, and if a dose was missed by 1+ hours, the side effects were severe. The withdrawal symptoms are more intense than I ever would have imagined and prescribing doctors do not warn patients against this. After beginning to taper off this medication, I experienced really dark thoughts and attempted suicide. I was in the ICU for a week and a psychiatric hospital for 4 weeks. Effexor almost cost me my life. Please don't risk yours by taking it.”

1 / 10
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Mikey77 · Taken for 1 to 6 months · January 28, 2020

“Have taken Prozac, Zoloft, bupropion XR on and off over the years. Nothing has snapped me out of a major depression episode quicker than this Effexor. Already take 80mg strattera for ADD. Venlafaxine kicked in almost immediately and has been tremendously helpful. I have read all the horror stories about going off of it but I was desperate for relief and this really did the trick. I don't want to be on it forever tho.”

10 / 10
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Prodigal · Taken for 2 to 5 years · December 19, 2019

“31/m. I have been on Effexor XR generics for 5 years after nearly committing suicide at the age of 26. It has completely gotten rid of my suicidal ideation as well as tremendously reducing my depression and anxiety. Without it, I'm quite certain that I would not be alive today. After trying to get off of it a couple times and having those bad feeling come back, I have become resigned to the fact that I will likely be on this drug for life, but am okay with that to be honest. I don't really have any side effects from the drug, at least not that I am aware of. The reason I give it 8 stars is because if you ever DO want to get off of it, the withdrawal symptoms are absolutely horrendous.”

8 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.