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Testosterone and Tiredness: What Users Say

Brand names: AndroGel, Xyosted, Depo-Testosterone, Jatenzo, Testim, Testopel Pellets, Androderm, Testopel, Fortesta, Striant, Aveed, Tlando, Kyzatrex, Undecatrex, Azmiro, Andro LA 200, Duratest, Testo-200, Natesto, FIRST-Testosterone, Depotest, Delatest, Everone, Andro-Cyp 100 Andro-Cyp 200 Depandro 100 Durathate 200 Histerone Testro-LA FIRST-Testosterone MC Vogelxo Testo-100 …show all brand names

Tiredness: mentioned by 25 users (4.7%)

Based on user experiences from 534 Testosterone reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

sexual dysfunction 5.4%
fatigue 4.7%
tiredness 4.7%
depression 4.5%
smell 3.0%
sweating 3.0%
mood swings 2.2%
anger 2.1%
headaches 2.1%
acne 1.9%

Reviews for Testosterone

Commonly mentioned side effects
  • M m...
  • January 1, 2015

Testosterone for Hypogonadism, Male "Been using for 2 years. Overall, it does what it's supposed to. At 52, I was just feeling out of it. Tired all the time, loss of energy, spare tire weight gain, and some erectile dysfunction. Tested at 278. Started with shots, and AndroGel combined, then just AndroGel for the last year. The shots were far more effective and cheaper, but my T levels would go way up then way down before the next shot. The gel keeps it steady. I have lost a lot of waistline, don't need naps anymore, and sex life is back to what it was in my 30s."

8 / 10
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152 Report
  • Anonymous
  • December 7, 2009

Testosterone for Hypogonadism, Male "Was feeling depressed, tired all the time and became extremely sore in leg muscles, sex drive low. I was only 26 at the time this all began. Had seen several doctors over next 2 years and they kept treating me with depression medication. Finally, a doctor tested my testosterone levels and it was 165, started January 2008 on testosterone shot 200mg every 2 weeks. Worked great for 8 months, my levels came up to 550, and I was feeling good. I began to get very tired and sore again in August 2008, my doctor switched me to AndroGel and immediately began to feel better. I used AndroGel for over a year now, my strength is back, sex drive is awesome, mood better, and I'm noticing muscle tone getting larger. Just recently had levels checked and came back high 1234, still using AndroGel."

8 / 10
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86 Report
  • UKF...
  • July 9, 2013

Testosterone for Hypogonadism, Male "I'm a 31-year-old male who has been on Axiron for a month. I noticed I was feeling tired and moody, but had no sexual side effects. I had my doc check my T levels, and it came back at 179. He sent me to a urologist who checked my T levels again, and it had dropped 10 points in 2 weeks to 169. He started me on Axiron with 2 pumps under each arm. This made me feel like I was going to come out of my skin, much like how ephedrine makes you feel. I called my doc, and he said to go to 1 pump under each arm. That seemed to work fine with no side effects. After 2 or 3 days, my energy levels and mood had improved. I went back to the doc after 2 weeks on Axiron to get my T level checked, and it was at 1300! I go back in 3 months to get checked again."

8 / 10
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51 Report

Frequently asked questions

  • Sku...
  • October 2, 2009

Testosterone for Hypogonadism, Male "I am a 46-year-old male. Memory and tiredness, slight depression. Diagnosed with low testosterone (222 on a scale of 200-800). Have used both Testim and Androgel. Like the way Androgel comes in a pump bottle and is not as sticky as Testim, but my wife and other women have commented that they like the smell of Testim. I now use Testim, applying one tube every other day because my wife says I'm more like myself at that dosage. Had an initial drop of testosterone to 201 when I first started treatment, but testosterone is now at 547 at the last lab. I feel much better."

7 / 10
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51 Report
  • Bow...
  • March 2, 2010

For Hypogonadism, Male "I have used the 1-ml once a month for several years, and if I don't get it on time, I start to feel tired, and my anxiety increases. Usually, after the dose, I start to feel better in a couple of days. After about 2-3 weeks, I start to feel tired again. The doctor won't increase the dosage, though, and I don't understand why. Also, PLEASE don't inject in your arm! There are several very good YouTube videos out there on how to inject in the leg. Take your time, it is very thick and oily, don't rush it. Make sure it makes it into the leg muscle, not just the skin."

8 / 10
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41 Report

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  • Rup...
  • September 17, 2014

Testosterone for Hypogonadism, Male "Went to see the doctor due to lethargy, low sex drive, fat gain, muscle loss, and a general 'blah' feeling. 41-year-old male. Was prescribed 100 mg/week. Self-injections. Within 4 weeks, was feeling about 75% better, and as time goes by... just keep getting better. Definitely a great medicine."

10 / 10
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27 Report
  • mps...
  • Taken for 5 to 10 years
  • April 28, 2014

For Hypogonadism, Male "Testosterone cypionate - Lost ability to recover from workouts, experiencing tiredness, and loss of libido in mid-40s. Doctor tested testosterone level, which was only 180. Began injections every 3 weeks, and my outlook on life changed almost immediately."

10 / 10
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28 Report
  • Mid...
  • Taken for 1 to 2 years
  • May 13, 2014

Testosterone for Hypogonadism, Male "I knew I was having low T and had it checked; won't bore you with the details, but it was extremely low. About four hours after applying Androgel, I felt a surge of well-being, almost giddy! Over a few days, it leveled out and my previous moodiness and tiredness were much improved. Worked great for a year, then insurance stopped covering Androgel. I switched to Fortesta. At four months, I just felt like it wasn't doing enough, and asked the doctor to increase my dose. He did, then at one year, my testosterone level was only 150! For some strange reason, I just don't absorb Fortesta. I don't want to deal with the smell of Testim, and so I'm starting shots soon. Can tell when I'm low!"

3 / 10
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29 Report
  • Ken...
  • Taken for 1 to 6 months
  • June 7, 2015

Testosterone for Hypogonadism, Male "I am a two-time testicular cancer survivor. My body no longer produces testosterone. I am 30 years old, and this will be for the rest of my life. I was on Androgel for about two and a half years. The last, I would say, eight months, I felt like complete crap. Depression and always tired and lethargic. Didn't feel like doing anything. No motivation for anything. I just had my second round of Testopel about a week and a half ago, and I love it. The first time I got it, I felt the difference within the first week. Same with this second go-round. I have more energy. The only problem I have is that on both times my incision site leaks, and one pellet did fall out. Other than that, I love this stuff."

10 / 10
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21 Report
  • Ken...
  • Taken for 1 to 6 months
  • June 7, 2015

Testosterone for Hypogonadism, Male "I am a two-time testicular cancer survivor. My body no longer produces testosterone. I am 30 years old, and this will be for the rest of my life. I was on Androgel for about two and a half years. The last, I would say, eight months, I felt like complete crap. Depression and always tired and lethargic. Didn't feel like doing anything. No motivation for anything. I just had my second round of Testopel about a week and a half ago, and I love it. The first time I got it, I felt the difference within the first week. Same with this second go-round. I have more energy. The only problem I have is that on both times my incision site leaks, and one pellet did fall out. Other than that, I love this stuff."

10 / 10
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21 Report
  • dal...
  • Taken for 1 to 6 months
  • June 20, 2013

For Hypogonadism, Male "I'm a 38-year-old married guy in the Dallas area and noticed that over the past few years, I had been growing stagnant. I had been sleeping a lot, not being able to concentrate at work, feeling tired and lethargic, and worst of all, my sex drive had just about disappeared. I'm on my second month and have to say WOW. My doctor started me on 120 mg of Testosterone Cypionate and upped my dosage to 140 mg about 2 shots ago. My first few weeks were okay, I had more energy, was able to sleep better at night, and improved libido. Now into my 2nd month, I'm as horny as I was at 19 and will probably go back to 120 mg since my wife can't keep up with me."

10 / 10
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23 Report
  • dal...
  • Taken for 1 to 6 months
  • June 20, 2013

For Hypogonadism, Male "I'm a 38-year-old married guy in the Dallas area and noticed that over the past few years, I had been growing stagnant. I had been sleeping a lot, not being able to concentrate at work, feeling tired and lethargic, and worst of all, my sex drive had just about disappeared. I'm on my second month and have to say WOW. My doctor started me on 120 mg of Testosterone Cypionate and upped my dosage to 140 mg about 2 shots ago. My first few weeks were okay, I had more energy, was able to sleep better at night, and improved libido. Now into my 2nd month, I'm as horny as I was at 19 and will probably go back to 120 mg since my wife can't keep up with me."

10 / 10
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23 Report
  • KYB...
  • Taken for less than 1 month
  • December 3, 2016

Testosterone for Hypogonadism, Male "OK guys, time out! I never thought I'd come to the defense of a consumer product, much less one that costs such an obscene amount of money, but: 1. There are a lot of guys on here complaining they had low testosterone (Low T) and giving their numbers before treatment. A large portion of them say Axiron took their numbers up into the 500 range. THIS IS WHAT THE DRUG IS SUPPOSED TO DO! If you're roughly between 348-1000, you're back to normal. Axiron worked. The fact that you still feel tired, or fatigued, or depressed is most likely due to other issues. I think there are too many guys on here expecting to take this drug and it to turn them into the Hulk, make them happy all the time, and provide for them sex whenever they want it."

8 / 10
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21 Report
  • Sku...
  • August 4, 2010

Testosterone for Hypogonadism, Male "See my previous comment on Testim in October 2009. Last December, I accidentally selected the wrong level of employer health insurance coverage. Result: no prescription coverage on our plan this year. With Testim at $330 per month, there was no way we could afford it, so I have been off Testim for 6 months. Boy, do I feel it. I'm tired and want to sleep all the time, melancholy and unmotivated to do anything. Auxilium was kind enough to give me a discount card for $75 off per month for 6 months. Going back to the pharmacy today and will pay the $255 difference for the next 6 months until health plan changes again. Last week's lab showed testosterone at 226, should be around 400 for my age (47). I never realized how important 'T' is."

8 / 10
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23 Report
  • Anonymous
  • March 18, 2012

For Hypogonadism, Male "I'm 33 years old and have no reason to be low on energy and motivation. In addition, I had a slight depression and an inability to focus, like my head was in a fog. Went to my doctor to find out what was wrong. I wasn't on any other medications, I'm 5' 10" and 160 pounds and otherwise very healthy. The doctor told me to exercise more, which I did, but was so tired that I just couldn't do anything. Went back to the doctor, and he did a full blood workup. Testosterone was 206 (350 - 1100 was normal at my lab), and he gave me a 200 mg/ml injection. All symptoms were gone, and my sex life has never been better. I feel like a new man, I had no idea just how much of an effect my low T was having on my life. This is my first injection."

7 / 10
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16 Report
  • Ano...
  • Taken for less than 1 month
  • June 11, 2012

Testosterone for Hypogonadism, Male "I am a 50-year-old male and pre-Axiron, testosterone tested out at 323 in the morning. I was feeling tired, sluggish, no sex drive, and falling asleep in the early evening. I started using 60 mg a day of Axiron. I noticed a huge increase in energy and increased libido during the first two days. Day three, I could feel the effects of Axiron tapering off, and I returned to feeling tired and sluggish. After one month of using Axiron, a morning test of my testosterone tested out at 257. Axiron dosage was just increased to 90 mg a day. I am not sure why Axiron would work initially and then stop working. I will give the 90 mg a day of Axiron a try for another month and have my testosterone re-tested."

2 / 10
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21 Report
  • Vip...
  • Taken for less than 1 month
  • May 21, 2012

Testosterone for Hypogonadism, Male "I have been on it for 5 days, 2 squirts each arm. On day 3, I started feeling nausea. Day 4, I only did 1 squirt each arm and still felt the same. Day 5, I did not take any. Will try again tomorrow. My levels were 167, and I am 38 years old. I was tired all the time, gained weight, bad mood, not very happy doing things I used to enjoy. I really want this to work because I want to feel normal again. Still trying to get used to the application, works better if you use a hair dryer, dries a lot faster."

6 / 10
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16 Report
  • Skr...
  • Taken for less than 1 month
  • January 2, 2014

For Hypogonadism, Male "Doc looked at my testosterone levels. I was feeling lethargic, moody, rapid weight loss due to lack of appetite, and no libido. Dr. prescribed testosterone cypionate injection, 200 mg a week intramuscular injection. 1st week not too noticeable of a change. 2nd week appetite increased, sense of well-being, increased libido, and most importantly, gained 12 pounds. Checked with doctor, and it wasn't edema or water weight (sodium retention), just solid weight gain. Used to have a gaunt face, now I'm filled out. Yeah, the injection is uncomfortable, but for the benefit, it's well worth it. I'm 44 and was 150 lbs. 3 weeks later, with a clean diet high in protein, moderate carbs, and no fried foods, I'm at 172 lbs. My goal is 185 at 5 ft 10 inches. I don't want to be Arnold, just a life."

10 / 10
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12 Report
  • Anonymous
  • December 1, 2010

Testosterone for Hypogonadism, Male "Initially, I had injections for a few years. It raised the red blood cell count significantly. Did not find a significant improvement with the use. T levels were below normal levels, and injections brought levels to 'normal.' Started using AndroGel a few years ago. Initially, 6 applications daily, then tweaking down and up to bring the red blood count to within a safe range. Had improved T levels with AndroGel. However, lacking sex drive, lack of energy, being tired, and not much improvement with erection. In short, a mixed feeling about its use."

3 / 10
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17 Report
  • Dr ...
  • January 10, 2021

For Hypogonadism, Male "I started with the testosterone HRT 3 months ago. 100 mg testosterone cypionate every 7 days. So far, no noticeable effects. Dr. has blood work every 6 weeks. Last test, my total T was what she said, 'borderline high,' and adjusted my dose to 75 mg. I don't feel any different. I still am tired all the time, no sex drive, no increase in energy or improved mood. Very frustrated, this medication was my last resort to feel better and improve my sex life and motivation. I am 42 years old. Clean diet, lift weights, and 30 min of cardio exercise 5 days a week. No smoking and quit all alcohol 2 years ago. Limit caffeine. What gives? Everyone I talk to that takes the testosterone injections says their life improves dramatically. They lose the weight, have the sex again, and motivation for life to get things done. I can barely get out of bed! I just want to have the sex again and not feel tired all the time! I think this testosterone is not actually testosterone but probably fake!"

1 / 10
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5 Report
  • Jus...
  • September 9, 2013

For Hypogonadism, Male "Testosterone levels must have started dropping off 4 to 5 years ago at 42. Over time, I lost interest in sex as the plumbing was not working as well as it should. Weight gain around the abdominal area and slow loss of muscle mass I thought was the natural aging process. Started to lose hair on my legs and was always tired. Started Depotest 6 months ago at 200 every three weeks. Roller coaster effect after 3 months but felt great. Switched to 200 every two and had no ill effects. Oily skin on my face and forehead was all. Dialed in at 100 per week and life is awesome. Caught it in time and my doctor feels there is no permanent tissue damage. Nocturnal erections are back to above normal, sex drive is great and erections are fully functional. Testosterone levels went from 187 to 700 range."

10 / 10
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14 Report
  • Doe...
  • June 10, 2016

Testosterone for Hypogonadism, Male "I have been using Axiron for 3 months and have experienced no noticeable positive effects. Still have low libido, no morning erections, lack of penile sensitivity, weak orgasms, and lethargy. Going to try injections ASAP."

1 / 10
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14 Report
  • bux...
  • August 3, 2011

"I am a 34-year-old male. Diagnosed with osteoporosis. I had a 900-pound steel beam fall on me in 2001. I have had many stomach surgeries and also have an ileostomy and lost my left kidney. I have been taking 300 mg of morphine for pain for the last ten years. I have been in deep, severe depression for years. I have been on 100 ml every 2 weeks of testosterone for a month, and it has changed my life. My level was 325. I have interest in life now and mentally feel really good. After 7-8 days, I start to feel tired and not so good, but after my shot, I feel great! Going to talk with the doctor to maybe do it every 7 to 10 days! Thanks for reading."

9 / 10
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10 Report
  • Anonymous
  • June 16, 2010

Testosterone for Hypogonadism, Male "Was diagnosed through a blood test at 231. After a month and a half, I was at 900, still feel weak and tired. I have a better mood and don't get upset easily anymore. My insurance leaves me paying $200 a month, so I'm switching to the needle. I like the smell personally, and people seem to like the smell of it too."

6 / 10
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11 Report
  • Mar...
  • Taken for 1 to 2 years
  • July 11, 2022

Testosterone for Hypogonadism, Male "Week 2-4, I feel like I’m 18 again with a painful 24/7 erection. On week 5, it starts to level out, by week 8, I’m a tired, depressed, couch-ridden mess."

3 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.