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Harvoni and Weakness: What Users Say

Weakness: mentioned by 12 users (3.0%)

Based on user experiences from 403 Harvoni reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 22.6%
fatigue 18.1%
insomnia 11.2%
tiredness 11.2%
nausea 8.2%
depression 4.7%
diarrhea 4.7%
upset stomach 4.2%
dizziness 3.7%
weakness 3.0%

Reviews for Harvoni

Commonly mentioned side effects
  • gra...
  • Taken for less than 1 month
  • July 17, 2016

For Hepatitis C "Today is the sixth day of taking Harvoni. I have had Hep C for over 30 years, I am sure from my wild days and sharing needles. I feel like something must be wrong with me. I am reading all of the other reviews, and everyone is reporting no or little side effects. I have been on this for six days, the first few days were a breeze, but the last few... I am experiencing diarrhea, nausea, I am so fatigued, I can barely get out of bed. I am weak and dizzy. None of these will make me quit taking the medicine, but I wonder how I will be able to do this for 12 weeks. I really don't have a choice, my numbers jumped from 4,000,000 to 10,000,000 and I have cirrhosis. I hope I get to the part where I feel better and more energetic than before soon!"

7 / 10
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58 Report
  • jus...
  • Taken for less than 1 month
  • August 2, 2016

For Hepatitis C "Thanks so much for sharing your stories. Glad to hear I am not the only one with sides and appear to be all over the place with most people and alleviate here and there. So there is hope yet. Into my second day and feel ghastly. Threw up today 4 hours after taking the pill. The nausea got me. If this occurs within 5 hours of taking a pill, you are supposed to take another one. Not this chick! Sides kicked in first day. Muscle/joint pain, yuk taste in mouth, no appetite, insomnia, nausea, mild headache, exhaustion, weakness. I've been languishing in bed for 1 and 1/2 days. Am female Australian, 65 years old, 55 kg and 5 feet tall. I believe the smaller you are the harder treatment is or else I am just super sensitive...jilly"

4 / 10
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39 Report
  • Sob...
  • Taken for 6 months to 1 year
  • March 22, 2017

For Hepatitis C "I am thankful I went on this drug. The only side effects I experienced were feeling tired and weak the first month. After that, I felt so good. Never did I get sick once. I even had more energy than I had before I started this treatment. My treatment lasted for 16 weeks. I hope this will encourage others to get treatment. You will live in peace knowing you are cured of this terrible disease."

10 / 10
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32 Report

Frequently asked questions

  • you...
  • Taken for 1 to 6 months
  • August 24, 2017

For Hepatitis C "10 weeks and cured of Hep C. Side effects were tiredness, loss of appetite, uncontrollable chills, weight loss, weakness. It's been 5 months after treatment, and now my 25 lb weight loss is permanent. I take oxycodone for the pain in my bones and back. Lost eyesight in one eye. My Hep C is gone, but my health is also gone."

3 / 10
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30 Report
  • Cat...
  • Taken for 1 to 6 months
  • June 23, 2018

For Hepatitis C "Took Harvoni for 12 weeks. Now have permanent tinnitus, 24/7 headache, neuropathy, joint pain, muscle pain and weakness, fatigue, floaters, hair loss, decreased lung function, and change in heartbeat... all from within 12 weeks. Had none of this before."

1 / 10
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29 Report

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  • fee...
  • May 20, 2016

For Hepatitis C "Day 6 on Harvoni. Headache problems, but a Motrin 800 and it really helps! Sleeping is not good as well, soft stools, and more anxiety than normal, thinking it is more in my head because I have never taken this. My emotions are higher than I would like them to be and also feel weak at times. I’m sure it is due to my lack of appetite. On the heels of that, I will start eating better. I feel blessed to know that this will be over soon, and I have heard many worse side effects. Whoever is going through this, I encourage you to stay with it! You can always lay down if you do not feel well. God bless you all, stay positive!"

7 / 10
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30 Report
  • Cra...
  • Taken for 1 to 6 months
  • July 14, 2019

For Hepatitis C "Took Harvoni a little more than 2 years ago and have been going downhill ever since. Soon after finishing my 3-month treatment, I came down with leukemia. CLL. Wish I would have stayed sick with HCV. I am very weak and have a lot of complaints about how I feel now compared to before, and I feel worse now."

4 / 10
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16 Report

More FAQ

  • Chi...
  • October 9, 2016

For Hepatitis C "I'm on day 11 of 84 (3-month treatment)... I take Harvoni at 6 pm religiously and find that I sleep through most of the symptoms. First 3 days were hard... nausea, restless legs, fatigue, weakness, and headaches... couldn't finish any gym sessions. But days 4-6 were 'miracle days'... I think my viral load dropped dramatically (will find out viral load in week 4 and week 12 and at 6 months). Zero viral load means the Hep C is non-active... which is as much as being cured as we can get. I have heard that a lot of patients are non-active in week 12 but are relapsing 6+ months after treatment. To prevent a relapse... I'm taking Spirulina, vitamin C & B complex, banana, and a handful of nuts and seeds every day. http://www.realnatural.org/chlorella-found-to-improve-hepatitis-c-infections/"

9 / 10
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20 Report
  • Spi...
  • September 29, 2016

For Hepatitis C "I am on my fifth week of a 12-week plan of Harvoni plus Ribavirin. I took part in an interferon plus Ribavirin treatment plan approximately 15 years ago that was not successful - it successfully kicked my ass though. With this current treatment, I felt no side effects the first two weeks, and then during the third and fourth weeks, I started becoming anemic with associated fatigue and shortness of breath. During week four and continuing into this fifth week, I continue to feel fatigue and shortness of breath, and also flu-like symptoms of weakness and full-body muscle aches. These symptoms are not completely debilitating but rather have significantly slowed my normally very active lifestyle."

4 / 10
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18 Report
  • Jen...
  • Taken for less than 1 month
  • December 24, 2019

For Hepatitis C "Do not fool yourself into thinking this is a miracle drug. I'm on my fourth week out of 12 weeks of treatment. I am EXTREMELY weak, depressed, all of my joints ache, stomach issues, and irritability I have never felt in my life, also rage. I won't stop treatment, because I don't want this disease to destroy me, just please don't fool yourself. I mean, it's different for everyone, but it's been awful for me. I wish everyone the best."

10 / 10
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11 Report
  • Ter...
  • May 31, 2017

For Hepatitis C "I have to agree with Anna. I am on my first week. I have had this infection since 2012 when I was diagnosed. I am very excited to be pure again. Completing this will be another success for me and only make me a stronger person. I have to say I feel really weak and have fatigue. I drink a whole lot of water and some protein shakes during my day. Just like anything, it is only one day at a time!!!"

10 / 10
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12 Report
  • scr...
  • Taken for less than 1 month
  • April 23, 2016

For Hepatitis C "DAY ONE: First dose @ 7 AM today. Minimal side effects. Weakness, fatigue toward evening. Gas. Diarrhea. Insomnia has been ongoing for approximately 3 years. Treatment naive. Type 1a. Fibrosis; 11/10/2015 -- 7.7 kPa F2 Baseline SCr: 0.8 mg/dL CrCl: 76 ml/min"

8 / 10
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3 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.