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Harvoni (ledipasvir / sofosbuvir) Drug Interactions

A total of 184 drugs are known to interact with Harvoni (ledipasvir / sofosbuvir).

  • 31 major drug interactions
  • 148 moderate drug interactions
  • 5 minor drug interactions

Show all medications in the database that may interact with Harvoni (ledipasvir / sofosbuvir).

Check for interactions

Type in a drug name to check for interactions with Harvoni (ledipasvir / sofosbuvir).

Most frequently checked interactions

View interaction reports for Harvoni (ledipasvir / sofosbuvir) and the medicines listed below.

  • Advil (ibuprofen)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Moxilin, Wymox, Biomox)
  • Benadryl (diphenhydramine)
  • clonazepam (Klonopin, Klonopin Wafer)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • hydrochlorothiazide (HydroDIURIL, Microzide, Oretic, Esidrix, Ezide, Aquazide H, Hydro Par, Carozide, Diaqua, Loqua)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Klonopin (clonazepam)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • melatonin (Melatonin Time Release, SGard, Bio-Melatonin, Health Aid Melatonin, VesPro Melatonin)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • methadone (Methadose, Methadone Diskets, Dolophine, Methadose Sugar-Free)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, RoxyBond, Percolone, Oxecta, Oxydose, Oxyfast, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol, Dazidox)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Acid Reducer, Zantac 150 EFFERdose, Taladine, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Deprizine, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Zantac Injection, Acid Relief, Sunmark Acid Reducer Maximum Strength, Acid Control 75, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • ribavirin (Copegus, Virazole, Moderiba, Rebetol, Ribasphere, RibaTab, RibaPak)
  • spironolactone (Aldactone, CaroSpir)
  • Suboxone (buprenorphine / naloxone)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Tylenol (acetaminophen)
  • Viagra (sildenafil)
  • Vitamin D3 (cholecalciferol)
  • Vitamins (multivitamin)
  • Xanax (alprazolam)

Harvoni (ledipasvir / sofosbuvir) disease interactions

There is 1 disease interaction with Harvoni (ledipasvir / sofosbuvir):

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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