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Efudex and Rash: What Users Say

Rash: mentioned by 7 users (5.5%)

Based on user experiences from 127 Efudex reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

pain 32.3%
itching 28.3%
redness 17.3%
swelling 11.0%
burning 9.4%
blisters 6.3%
discomfort 5.5%
peeling 5.5%
rash 5.5%
bleeding 3.9%

Reviews for Efudex

Commonly mentioned side effects
  • Nee...
  • Taken for less than 1 month
  • August 27, 2020

For Skin Cancer "I have been using the Efudex cream for 10 days now. I have come out in red spots on my face, but I am in no pain, as yet. I am wondering if I am using it correctly. The blotchy spots are crimson but not sore. Will it get worse because I was scared to use it, but so far so good as far as pain is concerned. I do look weird though with these red spots everywhere."

6 / 10
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  • Sir...
  • Taken for less than 1 month
  • October 15, 2020

For Skin Cancer "After completing my Efudex treatment, my skin seemed to get better, and then it turned out to get worse and worse, with red spots where I had applied the cream. My doctor could not understand why and prescribed me cortisone cream, which turned out to be much worse. Another doctor said I am cancer-free, but from now on, I have constantly broken capillaries on my face, and I am not able to do any inversions or put my head down. My skin is still irritated after 6 months since I stopped using Efudex. With very sensitive skin, you should be aware that this cream is not always the best option."

1 / 10
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67 Report
  • Anonymous
  • November 3, 2009

For Keratosis "I ended up in the hospital with a very serious allergic reaction to Efudex. Started with nausea and diarrhea, went into hives, swelling in my lips, mouth, all over my body. I have been out of the hospital for a week, my voice is still hoarse, I still have a rash, not feeling well at all. I'm on Prednisone to counteract the allergic reaction."

1 / 10
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116 Report

Frequently asked questions

  • Anonymous
  • November 3, 2009

For Keratosis "I ended up in the hospital with a very serious allergic reaction to Efudex. Started with nausea and diarrhea, went into hives, swelling in my lips, mouth, all over my body. I have been out of the hospital for a week, my voice is still hoarse, I still have a rash, not feeling well at all. I'm on Prednisone to counteract the allergic reaction."

1 / 10
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  • Man...
  • Taken for less than 1 month
  • April 20, 2020

For Basal Cell Carcinoma "I am up to my last day of treatment, day 21. I have treated my entire face once a day with Efudex and would never do it again. After the first couple of days, red spots start to appear, after a week, my face looked like a severe case of sunburn and felt like it. The intensity of the redness increased along with constant burning. By day 12, I was ready to give up but reminded myself I was over halfway. I didn't know how I could bear to apply more Efudex, but perseverance and willpower have been on my side. It is a painful experience, which I would only recommend as a last resort. Even today, I dread putting the cream on for the last time, but after that, I know each day will be a slow pace of healing. I look forward to the end result and hope all the discomfort is worth it."

4 / 10
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43 Report

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  • Lou...
  • March 31, 2017

For Actinic Keratosis "I used Efudex for 20 days. Got all the bearable symptoms of rash, redness, and sore skin. It took about 2 months for the redness to go completely. The main long-lasting side effect I have is that it's been six months, and I still have permanently very greasy, greasy skin on my nose and cheeks where I applied it. TIP: make sure you are not prone to rosacea before using it. I didn't know I was prone, but the Efudex triggered the adult rosacea I never knew I had. (Rosacea is like acne, it comes and goes but only in the place where I used the Efudex. It's embarrassing, and I don't like going in public during flare-ups.) I wouldn't recommend this treatment at all. It might be okay on small 2 cm spot treatments on the body, NOT THE FACE. Beware."

2 / 10
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  • Ell...
  • Taken for less than 1 month
  • July 6, 2021

For Basal Cell Carcinoma "My partner and I started applying Efudix at the same time. Me on my nose and forehead, he on the back of his neck. We've both used it before on specific lesions and had good results. He started showing red spots within 5 days. I had to wait 10 days before anything showed up, and I've taken photos of our journey together! His skin is far more reactive (skin damaged?) than mine, and after 3 weeks the back of his neck is a red, sore mass with oozing parts. Time for him to stop treatment and move to recovery. I've applied Efudix to the odd BCC on his back, and his skin has responded well and cleared up beautifully. I'm interested to see how the larger area of his neck will respond. Me, I'm still going. Some areas have reached the erosion stage and are itchy, while a couple of new red spots have just emerged. Looks like I'll be applying for another week until they scab over. Looking forward to the new skin!"

8 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.