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Fluconazole and Discharge: What Users Say

Brand names: Diflucan

Discharge: mentioned by 25 users (4.7%)

Based on user experiences from 530 Fluconazole reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

itching 22.5%
burning 10.6%
dizziness 8.9%
nausea 8.7%
diarrhea 7.2%
headaches 6.4%
swelling 5.5%
pain 4.9%
discharge 4.7%
rash 4.0%

Reviews for Fluconazole

Commonly mentioned side effects
  • Pre...
  • March 2, 2017

For Vaginal Yeast Infection "I had a yeast infection. Friday, I went to the doctor on Monday, who prescribed fluconazole and Canesten cream. When I took fluconazole 150 mg on Monday night, the next morning, I woke up with green discharge that smelled funny. I began to get worried, but I continued to watch it. During the day, the discharge wasn't green anymore, but it was brownish and thick. It looked more like whipped cream and felt plasticky to me. By the end of the day, my discharge was white and looked like the typical vaginal yeast infection. As the days went by, the discharge lessened, and the smell disappeared. I don't know if that's how the pill works to get rid of the yeast, but that was how my body reacted to it. My yeast infection is now completely gone."

7 / 10
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83 Report
  • Pre...
  • March 2, 2017

For Vaginal Yeast Infection "I had a yeast infection. Friday, I went to the doctor on Monday, who prescribed fluconazole and Canesten cream. When I took fluconazole 150 mg on Monday night, the next morning, I woke up with green discharge that smelled funny. I began to get worried, but I continued to watch it. During the day, the discharge wasn't green anymore, but it was brownish and thick. It looked more like whipped cream and felt plasticky to me. By the end of the day, my discharge was white and looked like the typical vaginal yeast infection. As the days went by, the discharge lessened, and the smell disappeared. I don't know if that's how the pill works to get rid of the yeast, but that was how my body reacted to it. My yeast infection is now completely gone."

7 / 10
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83 Report
  • Pre...
  • March 2, 2017

For Vaginal Yeast Infection "I had a yeast infection. Friday, I went to the doctor on Monday, who prescribed fluconazole and Canesten cream. When I took fluconazole 150 mg on Monday night, the next morning, I woke up with green discharge that smelled funny. I began to get worried, but I continued to watch it. During the day, the discharge wasn't green anymore, but it was brownish and thick. It looked more like whipped cream and felt plasticky to me. By the end of the day, my discharge was white and looked like the typical vaginal yeast infection. As the days went by, the discharge lessened, and the smell disappeared. I don't know if that's how the pill works to get rid of the yeast, but that was how my body reacted to it. My yeast infection is now completely gone."

7 / 10
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83 Report

Frequently asked questions

  • Tha...
  • Taken for less than 1 month
  • August 20, 2019

Fluconazole for Vaginal Yeast Infection "This worked great for me. Before taking the pill, I was itching and burning and had discharge. I was so embarrassed because I had never had one before. I also started to develop ulcers in my mouth, so the infection actually reached my mouth since it went untreated for 3 weeks. I was prescribed Diflucan. I took it on Friday, by Sunday, I started to feel better. On Sunday, I took the second pill. It is now Tuesday and my tongue ulcers are healing, my tonsils have gone down. The itching and burning stopped, but the irritation is still there whenever I wash my vagina with soap or wear certain panties."

10 / 10
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65 Report
  • joy...
  • Taken for less than 1 month
  • September 6, 2019

For Vaginal Yeast Infection "I had 2 recurrent yeast infections in a month. I had used clotrimazole cream and suppositories during this time. The itchiness went away with this treatment, so I knew it was a yeast infection, and the discharge was not smelly. The third time, I asked my doctor to give me fluconazole. With 100 mg on the first day, I saw improvement. Please don't suffer with yeast infections, take this pill. I did get a discharge after the first day, so hopefully all the yeast is coming off. The second dose cleared it out completely. I will recommend this product, but if you are allergic to it, then try some other yeast infection medication."

10 / 10
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60 Report

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  • Ive...
  • April 24, 2021

For Vaginal Yeast Infection "I was prescribed the pill a week ago. Stopped the itch, but started having discharge every day, doesn’t smell or anything yellow/light green. Not sure why I have a discharge when I never had a discharge before taking this pill, only the itch."

1 / 10
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51 Report
  • Not...
  • August 28, 2015

For Vaginal Yeast Infection "I'm not entirely sure why I am having such a hard time clearing up my yeast infection this time. This is now my 4th pill (after taking 3 of the 150 mg over the course of 3 weeks). I typically don't suffer from burning, itching, rashes...but the cottage cheese discharge is terrible. I took my 4th dose last night, it was 100 mg, and was expecting to not have any discharge this morning. Welp...still see it. It's not as much, but mid-day, wiped...still cottage cheese discharge. I am comforted by the ladies here saying it does take a few days. Just wondering why I've had to take so many this time and still not cured."

7 / 10
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56 Report

More FAQ

  • Aze...
  • March 9, 2016

For Vaginal Yeast Infection "After a round of antibiotics to clear up a UTI, I developed a severe yeast infection with itching, burning, and discharge. Called the doctor, and he prescribed the generic of Diflucan. Took one dose, and symptoms cleared completely in 24 hours. Took the second dose 3 days later and now symptom-free!!!! I do not post reviews often, but I needed to give back to someone who may be suffering like I was. These reviews provide relief when things feel like they can't get any worse. And this magic pill proved that things will get better with time."

10 / 10
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45 Report
  • tay...
  • Taken for less than 1 month
  • August 11, 2016

For Vaginal Yeast Infection "Had sex Friday night, went to work and used the bathroom, and wiped with cheap tissue. When I got home, I started itching and burning. It was so bad and unbearable. Good thing I had an appointment yesterday for a BP check-up. While I was there, I told my doctor my symptoms, and she prescribed me fluconazole. I took it yesterday around 7, and today around 7, I notice it's starting to work. I'm not itching or burning, plus it's pushing all the infection out. Every time I go pee, mount and mounts of discharge are coming out, plus I have to keep a pantyliner on because it makes you leak. That 150 mg did the trick for me. All I'm drinking is water and cranberry juice to help clean me out. Every med doesn't do the same for everyone, but it's fine for me. Hopefully, I don't experience this again!!"

9 / 10
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40 Report
  • Joa...
  • Taken for less than 1 month
  • October 14, 2018

For Vaginal Yeast Infection "I took this medication to treat a severe yeast infection. I used the two-day pill treatment. My doctor said to take the first one and then, if my symptoms did not completely disappear after 3 days, to take the second one. Took pill one and noticed my symptoms got worse. I took the second one with no luck either. My doctor then prescribed me the 7-day treatment following the two-day. My symptoms got slightly better but have not gone away completely. Intercourse is too painful to do anymore, and I still get itchiness, dryness, and abnormal discharge. This is extremely frustrating. Still looking for a cure :("

1 / 10
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19 Report
  • Chi...
  • July 6, 2016

For Vaginal Yeast Infection "I went to the doctor for a yeast infection (my first) and was given this. It seemed to help yesterday after I took it but woke up this morning with worse itching and massive amounts of discharge. Really hoping this will look up soon since I'm a newlywed and have things to do!"

6 / 10
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20 Report
  • Jam...
  • March 17, 2016

For Vaginal Yeast Infection "Fluconazole is AMAZING! I had a yeast infection. I took it on 3/14/16, and within only 12 hours, the swelling went down completely, and the itch stopped. Today, 3/16, I am completely itch-free, no discharge, no nothing! Definitely an awesome medication! Love it."

10 / 10
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18 Report
  • PJ2...
  • Taken for 1 to 6 months
  • May 10, 2016

For Vaginal Yeast Infection "I have chronic yeast infections. At first, I used Monistat, and my vag became so swollen I couldn't close my legs without it hurting, I was like that for 3 days. I went to the doctor, and he finally gave me Diflucan, and I've used it 3 times in the past, and it worked very quickly every time. But I have a yeast infection again, and I took Diflucan at about 6 pm, and it's now 1:32 am. I'm awake crying because the itching has gotten worse, and it's almost like I'm dripping discharge. This has never happened before. I'm just hoping it's a sign that the pill is clearing my vag of the infection..."

7 / 10
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18 Report
  • yea...
  • Taken for less than 1 month
  • February 25, 2016

For Vaginal Yeast Infection "I hate the over-the-counter creams. They do work, but they are messy. I take fluconazole right when I begin to itch or with my first dose of antibiotics and then again in 3 days. If I take it when I already have discharge and discomfort, I use an over-the-counter cream with it. All symptoms go away within a few hours. No more than 24 hours."

10 / 10
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14 Report
  • Poo...
  • August 9, 2019

For Vaginal Yeast Infection "I am on fluconazole 150 mg single dose for 4 weeks. The first day I took it gave relief with symptoms, but on the third, back to the same story. Itchy and discharge. I hate this. Still having the symptoms. After I finish with my dose, then I have to visit my doc. I hope I get away from this."

1 / 10
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12 Report
  • Kat...
  • Taken for 10 years or more
  • September 12, 2021

For Vaginal Yeast Infection "I’m someone who has chronic bladder and dental infections, so naturally, I’m no stranger to antibiotics or the yeast infections they cause. My first choice every time is Diflucan. Sometimes I have to take more than one dose, but it never fails me. For most infections, it’s a one-and-done treatment, and the relief happens pretty quickly, usually 12-24 hours. It’s even worked on oral thrush for me! Keep in mind that the infection can take many days and even up to a week to fully clear, but the symptoms start to resolve much, much sooner. Also, you’re likely to have an increase in discharge after taking this medication, and my theory is that it’s the deadened infection being expelled. I highly recommend every woman ask their doctor for some Diflucan to have on hand. It’s a lifesaver!"

10 / 10
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5 Report
  • Swe...
  • Taken for less than 1 month
  • April 5, 2016

For Vaginal Yeast Infection "I took one pill 150 mg last night. Within 3 hours, all symptoms had gone. But when I woke up at 8 a.m., I still have a little discharge, but around 3 hours my period is coming out. This med totally worked on me other than insert med."

8 / 10
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12 Report
  • Sue...
  • Taken for less than 1 month
  • January 8, 2021

For Vaginal Yeast Infection "I'm 31 and never had a yeast infection. I used a highly scented soap, which created some problems for me. On Monday, the itching was terrible, but it subsided when I used coconut oil. No symptoms on Tuesday. Wednesday, it was terrible! I noticed small amounts of discharge, which made me go to the pharmacy Thursday morning. Took Fluconazole at 8:30 a.m., and all of my symptoms were gone. Felt so good. HOWEVER, the next day, the itching was still there. It comes and goes. The discharge was gone, by the way. Hoping it will be gone soon."

3 / 10
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6 Report
  • Irr...
  • Taken for less than 1 month
  • July 30, 2019

For Vaginal Yeast Infection "Took fluconazole 150 mg, then took another one 7 days after. Symptoms got better, but the infection didn't go away at all. Still feel the itching and still see discharge 2 weeks after. I have to go see a doctor again for another way to get rid of the yeast infection."

1 / 10
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11 Report
  • Itc...
  • September 5, 2016

For Vaginal Yeast Infection "I was experiencing extreme and intense itching for almost a week straight. My period came, and I was fine after. I still went to the gyno, and she said there was still a little discharge, so she tested it. Didn't get a call back, but magically there was a prescription ready for me at my local pharmacy. I took one pill, and literally the next day, the intense itching was back! It's unbearable, I super can't live like this."

1 / 10
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7 Report
  • Bel...
  • July 7, 2019

For Vaginal Yeast Infection "My doctor prescribed me this, and it did not work. Itchiness went away for a while but came back. I took this pill at least four times, and the itchiness would go away, but discharge would still happen. My doctor was being rude and wouldn't give me a better medicine or something else since it wasn't working. So I'm still stuck with this situation, and my doctor won't do anything about it. I'm probably going to find something over the counter and hope that it works."

2 / 10
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9 Report
  • Anonymous
  • Taken for less than 1 month
  • November 16, 2014

For Vaginal Yeast Infection "I took the dosage on Thursday night. It is Sunday and I am still experiencing itchiness and discharge."

4 / 10
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94 Report
  • Anonymous
  • Taken for less than 1 month
  • July 8, 2019

For Vaginal Yeast Infection "I've taken this once before, and the next day I was cured. This time I took it, the next day my infection was itchier and had more discharge."

3 / 10
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24 Report
  • Gir...
  • Taken for less than 1 month
  • April 17, 2017

For Vaginal Yeast Infection "I've been taking them for over a week now, and my symptoms have just stayed the same, and there's more discharge than before. Is this meant to happen?"

1 / 10
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19 Report
  • dim...
  • October 19, 2015

For Vaginal Yeast Infection "I went to the doctor today, and I had been itching and light discharge for about three weeks. I took my pill at 11 a.m., and by 12 o'clock, I felt 100 percent better."

10 / 10
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14 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.