Donepezil and Headaches: What Users Say

• Anonymous
• Taken for less than 1 month
• February 23, 2019

For Mild Cognitive Impairment "I had TBI (traumatic brain injury) and have had a worse and worse time getting along in doing daily things, this medication does help some. It is much better than nothing at all. I know that depending on what other medications and conditions, serious side effects can happen. I have asthma and COPD, but I know how to treat that with various medications. A rescue inhaler is not enough, but I have other medications that are quite effective, including Combivent. There are many interactions, and I have been told by others that even genetics can cause adverse reactions with this medication. So far, the worst thing has been headaches, and with this, it is important to pay attention to the drug interactions to avoid problems. The other thing that I like about this medication is the cost, as unlike some of the other medications, this is very inexpensive."

• EGR...
• Taken for 1 to 6 months
• October 28, 2022

For Mild Cognitive Impairment "I've been diagnosed with Mild Cognitive Impairment (MCI) and started with 5 mg donepezil. Within a week, I started having constant headaches - mainly in my temples, similar to sinus-type headaches, but my usual sinus meds didn't touch it. I can't say whether I felt I was doing any better on the memory side, but it sure is hard to live with a constant headache. When I stop taking it, I feel MUCH better. But after a week off, I go back on the daily dosage and suffer through the headaches for a few weeks...."

• sen...
• Taken for 6 months to 1 year
• February 26, 2025

Donepezil "Trouble sleeping resulting in headaches caused by 'abnormal' dreams listed in less common side effects. For me, the better definition is intense dreams, awaking with a headache and difficulty sleeping thereafter."

• Cvc...
• Taken for 1 to 6 months
• August 30, 2024

For Alzheimer's Disease "I started taking Donepezil in April 2024 after being diagnosed with dementia. Immediately, I was overwhelmed with muscle cramps, dizziness, headaches, and nausea. I can’t sleep and am always tired. My doctor said I had to continue taking it as prescribed, that I’d get used to it. The dizziness and nausea eased up after 2-3 weeks, but the insomnia and muscle cramps are still terrible. Headaches are less frequent but severe and often keep me mostly homebound. My life has changed so much. I’m so sick that I hardly go out with friends, and they notice my withdrawal. Muscle cramps and unsteady walking have stopped my favorite exercise — cardio drumming. The nausea and vomiting have meant a loss of 12 pounds. My memory seems worse, though I know my family and friends, recall old times and major events. I’m confused about dates, like my wedding."

• SKC...
• October 26, 2015

Donepezil for Alzheimer's Disease "Trouble sleeping, stomach pain, headache, constipation, fever,"

• Mar...
• Taken for less than 1 month
• March 29, 2025

Donepezil for Alzheimer's Disease "Have had vivid dreams, am experiencing a headache, have not noticed any cognitive benefits, have noticed stomach upset noises, loss of appetite."

• Ano...
• Taken for less than 1 month
• September 13, 2025

Donepezil for Alzheimer's Disease "Side effects, headaches, achy joints and bones, drowsiness."