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Exparel User Reviews & Ratings (Page 3)

Exparel has an average rating of 5.7 out of 10 from a total of 74 reviews on Drugs.com. 50% of reviewers reported a positive experience, while 46% reported a negative experience.

Reviews for Exparel

Commonly mentioned side effects
  • But...
  • Taken for less than 1 month
  • November 2, 2021

For Pain "I am just now 96 hours after double hernia repair done robotically in a trauma surgical center. Fantastic care and the first use of Exparel on me worked fantastically. Other than a Tylenol once in a while, I have had no need for an opioid pain relief. I required some intestinal rearrangement and hernia patches resulting from a fall. Due to cancer and an accident, I have had a number of surgeries over the years that I'm sure I could have benefited from Exparel. One of those specifically would have been rotator cuff repair, done on a very damaged shoulder. I've been using that pain for my gauge as a number 10 on the pain scale for many years. I certainly will ask for it again if I require further surgery. Very effective for me."

10 / 10
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  • pam...
  • Taken for less than 1 month
  • May 3, 2025

For Postoperative Pain "I've had 10 surgeries in the last 5 years. Every surgery, I have woken up in horrible pain. Yesterday, I had metatarsalgia surgery ... woke up in zero pain! Right at 24 hours, and I'm thrilled with the Exparel! The instructions on the med say up to 72 hours? Bring it on! Happy camper here!"

10 / 10
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  • Cai...
  • Taken for less than 1 month
  • November 10, 2023

For Pain "I'm on day two after a dental implant surgery (abutment placement) and have felt minimal pain-just soreness in my cheek. I'd honestly say it works too well. The day after surgery, I didn't really feel any pain when I woke up and did a little too much because I ended up overestimating my activity levels. I ended up feeling super winded, and coupled with experiencing the side effect of decreased appetite and riding out the lingering effects of anesthetic from the day before, I felt kind of bad when I realized I hadn't eaten for 12 hours. On one hand, I liked that hydrocodone kept me from doing too much and hurting myself, but on the other hand, Exparel has been practically painless and I feel mostly like myself. I'm not sure how I'd feel if I had to take it for any other procedures, however."

8 / 10
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  • unk...
  • Taken for less than 1 month
  • August 5, 2021

For Pain "I had Exparel Slow Release to remove anal warts. I was told it is a topical anesthetic that should provide relief from pain for three days. And it did exactly that! I had zero pain, and I know what anal pain feels like as I'd had two anal fistulectomies in the past. I haven't studied the specs for this medication, but it performed exactly as was explained to me prior to the surgery."

10 / 10
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  • Liz...
  • Taken for less than 1 month
  • December 11, 2024

For Postoperative Pain "I had Exparel before arthroscopic shoulder surgery. Man - this stuff is amazing! Within 10 min, my entire arm was dead weight. I felt absolutely no pain after surgery. I took NSAIDs and acetaminophen for inflammation, but I had no pain at all. On day two, post-surgery, the numbness started to wear off. I’m at day 4.5 post-surgery, and while I have regained feeling in most of my arm, the area where the three incisions are is still relatively numb. I expect to have full feeling back tomorrow. This numbness meant I really have not needed any narcotic pain medications. I did take narcotics on the second and third night to help me sleep (sleeping is just not easy), and because I was worried the pain would kick in. But it never really did. I’m not sure what tomorrow will be like when it’s no longer numb at the incision sites, but I’m thrilled that I have not had much pain at all and have not needed a bunch of narcotics."

10 / 10
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  • Lau...
  • Taken for less than 1 month
  • December 24, 2020

For Pain "I was given Exparel as a nerve block for a bunionectomy. This was a miracle drug for me. I could not feel my foot at all for 3 days and it didn’t fully wear off for a full 7 days. This is a very painful surgery and this medicine was a godsend to get me over the worst days. I only had to take a few narcotic pills and was able to toss the rest. I highly recommend this medicine for this particular surgery!"

10 / 10
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  • Ali...
  • Taken for less than 1 month
  • September 23, 2020

For Pain "I had Exparel following laparoscopic surgery and had a lot of anxiety about postsurgical pain. I have had no pain, and it is almost 24 hours! Amazing! I have to have another surgery in 4 weeks and will definitely ask for it for pain relief. Now I will be more confident going into surgery knowing that I won’t be in so much pain."

10 / 10
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  • ABC...
  • Taken for less than 1 month
  • September 28, 2021

For Pain "I had Exparel administered during my wisdom teeth removal, and its effect was/is truly magical. I had 4 teeth removed, for more context. I had some pain post-op on the first day, and very tolerable pain the second and third day. I’m on my fourth day and the pain is virtually nonexistent. I have been taking ibuprofen as directed, which I’m sure helps, but my recovery experience has been far, far smoother than anyone else I’ve known who has had the procedure done and had not used Exparel. I’m so happy I didn’t have to take an opioid and that it was so effective on its own."

10 / 10
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  • ADR...
  • Taken for less than 1 month
  • April 15, 2023

For Pain "I just had a lumbar artificial disc replacement between L4 and L5 - major back surgery. They go through the stomach to access the spine and then use a tool to open up my collapsed bone-on-bone disc so they can put in a new artificial disc and restore the disc height and movement. I am amazed by how little pain I have had since the surgery, and I have every reason it’s mostly credited to this medication. I actually had to stop myself from walking more than was recommended because I feel zero nerve pain, etc. It’s supposed to last up to 70 hours, so I’m a bit nervous about when it wears off (it’s been 50 hours so far)."

10 / 10
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  • Jes...
  • Taken for less than 1 month
  • December 24, 2019

For Pain "Was given an injection of Exparel 3 weeks ago to put a drain in my mouth after oral surgery. That area of my mouth is still numb along with 3 teeth. I hope it wears off at some point."

1 / 10
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14 Report
  • EGa...
  • Taken for less than 1 month
  • March 23, 2018

For Pain "My son was given Exparel after having his wisdom teeth extracted. It did not provide him much pain relief at all. I would not recommend it for oral surgery."

3 / 10
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17 Report
  • Mel...
  • Taken for less than 1 month
  • June 13, 2019

For Pain "They gave Exparel to me after surgery. I'd say it was a joke, or it wasn't literally torture. Wouldn't wish it on my worst enemy."

1 / 10
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12 Report
  • Mat...
  • November 3, 2020

For Pain "Was given post-hemorrhoidectomy. Wore off within 2 hours. Not worth it. I understand not all cases are the same, but this was ridiculous!"

1 / 10
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  • Moa...
  • February 24, 2021

For Pain "Had a tooth extracted, it didn’t do anything, not a lick. I was immediately in excruciating pain. So I basically just threw that money out the window."

1 / 10
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6 Report
  • Sam...
  • Taken for less than 1 month
  • December 20, 2019

For Pain "Was given Exparel during implant oral surgery. Never had any pain. For oral surgery, would recommend always."

10 / 10
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  • PLC...
  • Taken for less than 1 month
  • September 26, 2020

For Pain "I was told Exparel lasts 72 hours, I have paid $450 for “a big bottle” and found it worn off after 12 hours. I was in excruciating pain after."

5 / 10
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  • Kik...
  • April 11, 2024

For Postoperative Pain "I had Exparel injection for two anal polyp excision and I felt no pain post surgery. This injection worked for me."

10 / 10
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  • And...
  • July 21, 2020

For Pain "Had rotator cuff surgery 4 days ago, was given Exparel. Almost no post-surgical pain. Amazing. Given a small prescription of opiate that I not needed at all. Very pleased."

10 / 10
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  • San...
  • Taken for less than 1 month
  • May 3, 2023

For Pain "The worst pain ever experienced. Are we in some kind of sick experiment?"

1 / 10
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  • Exp...
  • Taken for less than 1 month
  • June 22, 2023

For Pain "I was given this to help control pain from a tummy tuck. It did absolutely nothing, and I woke up in the recovery room with 10/10 pain. I had no relief at all."

1 / 10
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  • Jil...
  • Taken for less than 1 month
  • October 15, 2023

For Pain "Great! Led to a pain-free wisdom tooth recovery without Percocet or other opioid medications. Only needed ibuprofen and Tylenol."

10 / 10
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  • Anonymous
  • August 26, 2021

For Pain "Have had it twice, two surgeries. Absolutely no pain! Allows for early movement and speedy recovery. (I’m 94 and so happy to be up and around again so soon!)"

10 / 10
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  • Sal...
  • Taken for less than 1 month
  • June 29, 2018

For Pain "Thought Exparel was great, did not need any pain meds for 2 days."

10 / 10
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  • Lov...
  • Taken for less than 1 month
  • October 23, 2021

For Pain "I had a mass removed, and today is the second day, and I feel no pain at all! The Exparel has given me 100 percent relief."

10 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.