Exparel Interactions
There are 129 drugs known to interact with Exparel (bupivacaine liposome), along with 3 disease interactions. Of the total drug interactions, 23 are major, 104 are moderate, and 2 are minor.
- View all 129 medications that may interact with Exparel
- View Exparel disease interactions (3)
Most frequently checked interactions
View interaction reports for Exparel (bupivacaine liposome) and the medicines listed below.
- acetaminophen
- amlodipine
- Benadryl (diphenhydramine)
- cefdinir
- cephalexin
- clindamycin
- diazepam
- Dilaudid (hydromorphone)
- doxycycline
- famotidine
- fentanyl
- fluconazole
- folic acid
- gabapentin
- hydroxyzine
- ibuprofen
- Keflex (cephalexin)
- ketorolac
- Linzess (linaclotide)
- Lovenox (enoxaparin)
- methocarbamol
- metronidazole
- omeprazole
- ondansetron
- prednisone
- tramadol
- trazodone
- vancomycin
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
Exparel disease interactions
There are 3 disease interactions with Exparel (bupivacaine liposome) which include:
Report options
More about Exparel (bupivacaine liposome)
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- Side effects
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: local injectable anesthetics
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
