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Endometrial Biopsy


Endometrial biopsy is a procedure to remove a tissue sample from the lining of your uterus. This procedure is done through your vagina.


Before your procedure:

  • Write down the correct date, time, and location of your procedure.
  • Ask your healthcare provider if you will be able to drive home after the procedure. You may need to have someone drive you home.
  • Ask your healthcare provider if you need to stop using aspirin or any other prescribed or over-the-counter medicine before your procedure or surgery.
  • Bring your medicine bottles or a list of your medicines when you see your healthcare provider. Tell your provider if you are allergic to any medicine. Tell your provider if you use any herbs, food supplements, or over-the-counter medicine.
  • Tell your healthcare provider if you know or think you might be pregnant.
  • Tell your healthcare provider if you have a blood disorder or have had a bleeding problem in the past.
  • You may need to take an NSAID before your procedure to lessen the pain. Follow your healthcare provider's instruction on when to take it.

The day of your procedure:

  • You or a close family member will be asked to sign a legal document called a consent form. It gives healthcare providers permission to do the procedure or surgery. It also explains the problems that may happen, and your choices. Make sure all your questions are answered before you sign this form.
  • You may need a blood or urine test before your procedure to make sure you are not pregnant. Talk to your healthcare provider about these or other tests you may need. Write down the date, time, and location for each test.


What will happen:

You will be awake during the procedure. You will lie on a table and put your feet in stirrups. Your healthcare provider may do a pelvic exam first to check for any problems. An ultrasound or hysteroscope (tube with a light and a camera on the end) may be used before the procedure to see inside the uterus to find the best spot to get the tissue sample. Your healthcare provider will then insert a speculum into your vagina. This is the same tool used during a pap smear. The speculum allows your healthcare provider to see inside your vagina to your cervix. He may need to numb your cervix. Your healthcare provider will insert a small tube into your vagina and cervix to remove a piece of tissue from the lining of your uterus. The tissue sample will be sent to a lab to be tested.

After your procedure:

Do not get up until your healthcare provider says it is okay. When your healthcare provider sees that you are okay, you may go home.


  • You cannot make it to your procedure.
  • You have a fever.
  • You get a cold or the flu.
  • You have questions or concerns about your procedure.

Seek Care Immediately if

  • The problems for which you are having the procedure get worse.


You could get an infection after your procedure. Your uterus may be damaged which can cause heavy bleeding and pain. If this happens, you may need surgery to repair the damage. If this procedure is not done, your signs and symptoms may get worse or a serious condition such as cancer could be missed.

Care Agreement

You have the right to help plan your care. Learn about your health condition and how it may be treated. Discuss treatment options with your healthcare providers to decide what care you want to receive. You always have the right to refuse treatment.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.