Endometrial Biopsy

Medically reviewed by Drugs.com. Last updated on May 4, 2025.

• Discharge
• Inpatient
• Precare
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WHAT YOU NEED TO KNOW:

Endometrial biopsy is a procedure to remove a tissue sample from the lining of your uterus. This procedure is done through your vagina.

HOW TO PREPARE:

The week before your procedure:

• Arrange to have someone drive you home after your procedure and stay with you for 24 hours.
• Tell your surgeon about all medicines you currently take. He or she will tell you if you need to stop any medicine before your procedure, and when to stop. He or she will tell you which medicines to take or not take on the day of your procedure.

The night before your procedure:

You may be told not to eat or drink anything after midnight.

The day of your procedure:

• You or a close family member will be asked to sign a legal document called a consent form. It gives healthcare providers permission to do the procedure or surgery. It also explains the problems that may happen, and your choices. Make sure all your questions are answered before you sign this form.
• You may need a blood or urine test before your procedure to make sure you are not pregnant.
• You may need to take an NSAID before your procedure to decrease swelling and pain. Follow your healthcare provider's instruction on when to take it.
• An anesthesiologist will talk to you before your procedure. You may need medicine to numb your cervix. Tell him or her if you or anyone in your family has had a problem with anesthesia in the past.

WHAT WILL HAPPEN:

What will happen:

You will be awake during the procedure. An ultrasound or hysteroscope (tube with a light and a camera on the end) may be used. This helps your healthcare provider see inside your uterus to find the best spot to get the tissue sample. He or she will then insert a speculum into your vagina. This is the same tool used during a Pap smear. The speculum allows your healthcare provider to see inside your vagina to your cervix. He or she may need to numb your cervix. Your healthcare provider will insert a small tube into your vagina and cervix to remove a piece of tissue from the lining of your uterus. The tissue sample will be sent to a lab to be tested.

After your procedure:

Do not get up until your healthcare provider says it is okay. When your healthcare provider sees that you are okay, you may be able to go home. You may have mild pain, cramping, or spotting for a few days after your procedure.

CONTACT YOUR HEALTHCARE PROVIDER IF:

• You have a fever.
• You get a cold or the flu.
• You have questions or concerns about your procedure.

Risks

You could get an infection after your procedure. Your uterus may be damaged. Damage can cause heavy bleeding and pain. You may need surgery to repair the damage.

Drugs used to treat this and similar conditions

Care Agreement

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