Endometrial Biopsy

Medically reviewed by Drugs.com. Last updated on May 4, 2025.

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Endometrial biopsy is a procedure to remove a tissue sample from the lining of your uterus. This procedure is done through your vagina.

WHILE YOU ARE HERE:

Before your procedure:

• Informed consent is a legal document that explains the tests, treatments, or procedures that you may need. Informed consent means you understand what will be done and can make decisions about what you want. You give your permission when you sign the consent form. You can have someone sign this form for you if you are not able to sign it. You have the right to understand your medical care in words you know. Before you sign the consent form, understand the risks and benefits of what will be done. Make sure all your questions are answered.
• NSAIDs decrease swelling and pain. You may need to take an NSAID before your procedure. Follow your healthcare provider's instruction on when to take it.

During your procedure:

You will be awake during the procedure. An ultrasound or hysteroscope (tube with a light and a camera on the end) may be used. This helps your healthcare provider see inside your uterus to find the best spot to get the tissue sample. He or she will then insert a speculum into your vagina. This is the same tool used during a Pap smear. The speculum allows your healthcare provider to see inside your vagina to your cervix. He or she may need to numb your cervix. Your healthcare provider will insert a small tube into your vagina and cervix to remove a piece of tissue from the lining of your uterus. The tissue sample will be sent to a lab to be tested.

Drugs used to treat this and similar conditions

After your procedure:

Do not get up until your healthcare provider says it is okay. When your healthcare provider sees that you are okay, you may be able to go home. You may have mild pain, cramping, or spotting for a few days after your procedure.

RISKS:

You could get an infection after your procedure. Your uterus may be damaged. Damage can cause heavy bleeding and pain. You may need surgery to repair the damage.

CARE AGREEMENT:

You have the right to help plan your care. Learn about your health condition and how it may be treated. Discuss treatment options with your healthcare providers to decide what care you want to receive. You always have the right to refuse treatment.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Further information

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