Acute Chest Syndrome

Medically reviewed by Drugs.com. Last updated on May 4, 2025.

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Acute chest syndrome (ACS) is a complication of sickle cell disease (SCD). During ACS, sickled red blood cells block the blood vessels in the lungs. This causes lung damage and prevents the lungs from receiving oxygen. ACS can happen a few days after a sickle cell crisis begins, or after you get a lung infection. ACS is a medical emergency.

DISCHARGE INSTRUCTIONS:

Call your local emergency number (911 in the US) or have someone call if:

• You stop breathing.
• You lose consciousness or cannot be woken.
• You have chest pain and cough up blood.

Seek care immediately if:

• Your symptoms return.

Drugs used to treat this and similar conditions

Call your doctor if:

• You have questions or concerns about your condition or care.

Help prevent ACS:

• Take all medicines as directed. You may need to take medicine to help your body make red blood cells that are less likely to sickle. This may help prevent ACS. You may also need to take medicine to prevent a lung infection that could increase your risk for ACS.
• Drink liquids as directed. Dehydration can increase your risk for ACS. Ask how much liquid to drink each day and which liquids are best for you.
• Ask about vaccines you may need. Your provider can tell you if you should also get vaccines not listed below:
  • Ask your healthcare provider about the flu and pneumonia vaccines. All adults should get the flu (influenza) vaccine as soon as recommended each year, usually in September or October. The pneumonia vaccine is recommended for all adults aged 50 or older to prevent pneumococcal disease, such as pneumonia. Adults aged 19 to 49 years who are at high risk for pneumococcal disease should also receive the vaccine. You may need 1 dose or 2. The number depends on the vaccine used and your risk factors.
  • COVID-19 vaccines are given to adults as a shot. At least 1 dose of an updated vaccine is recommended for all adults. COVID-19 vaccines are updated throughout the year. Adults 65 or older need a second dose of updated vaccine at least 4 months after the first dose. Your healthcare provider can help you schedule all needed doses as updated vaccines become available.
• Wash your hands often. Handwashing can help prevent illness. Wash your hands before you prepare or eat food, and after you use the bathroom.
• Do not smoke. Nicotine and other chemicals in cigarettes and cigars can cause lung damage. They can also increase your risk for ACS. Ask your healthcare provider for information if you currently smoke and need help to quit. E-cigarettes or smokeless tobacco still contain nicotine. Talk to your healthcare provider before you use these products.

Follow up with your doctor as directed:

Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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