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Acute Chest Syndrome


Acute chest syndrome (ACS) is a complication of sickle cell disease (SCD). During ACS, sickled red blood cells block the blood vessels in the lungs. This causes lung damage and prevents the lungs from receiving oxygen. ACS can happen a few days after a sickle cell crisis begins, or after you get a lung infection. ACS is a medical emergency.


Call 911 or have someone else call for any of the following:

  • You stop breathing.
  • You lose consciousness or cannot be woken.
  • You have chest pain and cough up blood.

Seek care immediately if:

  • Your symptoms return.

Contact your healthcare provider if:

  • You have questions or concerns about your condition or care.

Help prevent ACS:

  • Take all medicines as directed. You may need to take medicine to help your body make red blood cells that are less likely to sickle. This may help prevent ACS. You may also need to take medicine to prevent a lung infection that could increase your risk for ACS.
  • Drink liquids as directed. Dehydration can increase your risk for ACS. Ask how much liquid to drink each day and which liquids are best for you.
  • Ask about vaccinations. Vaccinations can help prevent a viral infection. Get a flu shot every year as directed. You may also need a pneumonia vaccine.
  • Wash your hands frequently. Handwashing can help prevent illness. Wash your hands before you prepare or eat food, and after you use the bathroom.
  • Do not smoke. Nicotine and other chemicals in cigarettes and cigars can cause lung damage. They can also increase your risk for ACS. Ask your healthcare provider for information if you currently smoke and need help to quit. E-cigarettes or smokeless tobacco still contain nicotine. Talk to your healthcare provider before you use these products.

Follow up with your doctor as directed:

Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.