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Zydelig

Generic Name: Idelalisib (eye del a LIS ib)
Brand Name: Zydelig

Medically reviewed: April 4, 2018

Warning

  • Very bad and sometimes deadly liver problems have happened with Zydelig (idelalisib). You will need to have your liver checked while you take this drug. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • It is common to have loose stools (diarrhea) with Zydelig (idelalisib). Sometimes, very bad or deadly diarrhea has happened with Zydelig (idelalisib). Call your doctor right away if you have very bad diarrhea or the number of bowel movements you have in a day goes up by 6 or more.
  • Very bad and sometimes deadly bowel problems have happened with Zydelig (idelalisib). These are problems like swelling and tears in the bowel wall. Call your doctor right away if you are throwing up blood or you have throw up that looks like coffee grounds. Call your doctor right away if you have black, tarry, or bloody stools; fever or chills; upset stomach or throwing up; or stomach pain that is new or worse.
  • Very bad and sometimes deadly lung problems have happened with Zydelig (idelalisib). Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • Very bad and sometimes deadly infections have happened in patients who take Zydelig (idelalisib). If you have any infection, are taking antibiotics now or in the recent past, or have had many infections, talk with your doctor.
  • Call your doctor right away if you have any signs of infection like fever, chills, flu-like signs, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or a wound that will not heal.

Uses of Zydelig:

  • It is used to treat a type of leukemia.
  • It is used to treat a type of lymphoma.

What do I need to tell my doctor BEFORE I take Zydelig?

  • If you have an allergy to Zydelig (idelalisib) or any part of Zydelig (idelalisib).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are taking any of these drugs: Carbamazepine, phenytoin, rifampin, or St. John's wort.
  • If you are taking any drugs that can raise the chance of liver problems. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you are taking any drugs that can cause loose stools (diarrhea). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you are taking bendamustine or rituximab to treat a type of lymphoma called follicular B-cell non-Hodgkin lymphoma.
  • If you are breast-feeding. Do not breast-feed while you take Zydelig (idelalisib) or for 1 month after you stop Zydelig (idelalisib).

This is not a list of all drugs or health problems that interact with Zydelig (idelalisib).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zydelig (idelalisib) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Zydelig?

  • Tell all of your health care providers that you take Zydelig (idelalisib). This includes your doctors, nurses, pharmacists, and dentists.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • If you are 65 or older, use Zydelig (idelalisib) with care. You could have more side effects.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use birth control that you can trust.
  • If you are a man and your sex partner gets pregnant while you take Zydelig (idelalisib) or within 3 months after your last dose, call your doctor right away.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Zydelig (idelalisib). Talk with your doctor.
  • Use birth control that you can trust during treatment and for 1 month after treatment ends.
  • If you get pregnant while taking Zydelig (idelalisib) or within 1 month after your last dose, call your doctor right away.

How is this medicine (Zydelig) best taken?

Use Zydelig (idelalisib) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Swallow whole. Do not chew, break, or crush.
  • To gain the most benefit, do not miss doses.
  • Keep taking Zydelig (idelalisib) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it has been 6 hours or more since the missed dose, skip the missed dose and go back to your normal time.
  • Do not give 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat; dizziness; fast breathing; or confusion.
  • Any unexplained bruising or bleeding.
  • Mouth irritation or mouth sores.
  • Night sweats.
  • Swelling in the arms or legs.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Zydelig?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Loose stools (diarrhea).
  • Headache.
  • Not hungry.
  • Feeling tired or weak.
  • Not able to sleep.
  • Signs of a common cold.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Zydelig?

  • Store in the original container at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Zydelig (idelalisib) is refilled. If you have any questions about Zydelig (idelalisib), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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