Skip to Content


Generic Name: Elbasvir and Grazoprevir (ELB as vir & graz OH pre vir)
Brand Name: Zepatier

Medically reviewed by Last updated on Nov 5, 2020.


  • You will be tested for hepatitis B before starting Zepatier (elbasvir and grazoprevir). In people who have had hepatitis B or carry the virus, the virus has become active again during or after treatment with drugs like this one. This can lead to severe and sometimes deadly liver problems. People with hepatitis B and hepatitis C will be watched closely during and after treatment.

Uses of Zepatier:

  • It is used to treat long-term hepatitis C infections.
  • This medicine may be used with other drugs to treat hepatitis C. If you are also taking other drugs to treat hepatitis C, talk with the doctor about the risks and side effects that may happen.

What do I need to tell my doctor BEFORE I take Zepatier?

  • If you are allergic to Zepatier (elbasvir and grazoprevir); any part of Zepatier (elbasvir and grazoprevir); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have ever had liver problems other than hepatitis C.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Zepatier (elbasvir and grazoprevir), like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with Zepatier (elbasvir and grazoprevir).
  • If you are taking St. John's wort. Do not take St. John's wort with Zepatier (elbasvir and grazoprevir). This medicine may not work as well.

This is not a list of all drugs or health problems that interact with Zepatier (elbasvir and grazoprevir).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zepatier (elbasvir and grazoprevir) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Zepatier?

  • Tell all of your health care providers that you take Zepatier (elbasvir and grazoprevir). This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine interacts with many other drugs. The chance of side effects may be raised or how well Zepatier (elbasvir and grazoprevir) works may be lowered. Check with your doctor and pharmacist to make sure that it is safe for you to take Zepatier (elbasvir and grazoprevir) with all of your other drugs (prescription or OTC, natural products, vitamins).
  • Do not stop taking Zepatier (elbasvir and grazoprevir) without calling the doctor who ordered it for you.
  • Liver problems have happened with Zepatier (elbasvir and grazoprevir). Liver problems have also gotten worse in people who already have them. Rarely, this has been deadly. If you have questions, talk with the doctor.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Zepatier) best taken?

Use Zepatier (elbasvir and grazoprevir) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Do not take Zepatier (elbasvir and grazoprevir) out of the blister pack until you are ready to take it. Take Zepatier (elbasvir and grazoprevir) right away after opening the blister pack. Do not store the removed drug for future use.
  • Keep taking Zepatier (elbasvir and grazoprevir) as you have been told by your doctor or other health care provider, even if you feel well.
  • It is important that you do not miss or skip a dose of Zepatier (elbasvir and grazoprevir) during treatment.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you are not sure what to do if you miss a dose, call your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Feeling very tired or weak.

What are some other side effects of Zepatier?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Zepatier?

  • Store in the original container at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Zepatier (elbasvir and grazoprevir), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions