Generic Name: bendamustine (BEN-da-MUS-teen)
Brand Name: Treanda
Treanda is used for:
Treating chronic lymphocytic leukemia (CLL). It is also used to treat a certain type of non-Hodgkin lymphoma (NHL) in certain patients. It may also be used for other conditions as determined by your doctor.
Treanda is an alkylating agent. It works by blocking the growth of cancer cells.
Do NOT use Treanda if:
- you are allergic to any ingredient in Treanda (including mannitol)
- you have moderate to severe liver problems
- you have severe kidney problems
Contact your doctor or health care provider right away if any of these apply to you.
Before using Treanda:
Some medical conditions may interact with Treanda. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have an infection (eg, HIV, shingles), liver or kidney problems, heart problems (eg, heart failure, irregular heartbeat), high blood pressure, high blood uric acid levels, low blood potassium levels, bone marrow problems (eg, low white blood cell, red blood cell, or platelet levels), skin problems, or other types of cancer
- if you smoke or have a history of tobacco use
Some MEDICINES MAY INTERACT with Treanda. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Allopurinol because the risk of a severe skin reaction may be increased
- Ciprofloxacin or fluvoxamine because they may increase the risk of Treanda's side effects
- Omeprazole because it may decrease Treanda's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Treanda may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Treanda:
Use Treanda as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Treanda is given as an injection at your doctor's office, hospital, or clinic. If you will be using Treanda at home, a health care provider will teach you how to use it. Be sure you understand how to use Treanda. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Treanda if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- If Treanda accidentally spills on your skin, wash it off right away with soap and water.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Treanda, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Treanda.
Important safety information:
- Treanda may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Treanda with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Treanda may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems, which may not go away, and sometimes death. Get medical help right away if you have signs such as red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- If you may become pregnant, you must use an effective form of birth control while you receive Treanda and for 3 months after you stop taking it. If you have questions about effective birth control, talk with your doctor.
- Men who take Treanda should always use a condom when having sex with a woman who may become pregnant. Do this for as long as you take Treanda and for 3 months after you stop taking it. If you think your sexual partner may be pregnant while you are taking Treanda, contact your doctor right away.
- Treanda may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection such as fever, sore throat, rash, or chills.
- A serious and possibly fatal condition called tumor lysis syndrome (TLS) has been reported in patients taking Treanda. Contact your doctor right away if you develop symptoms such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness. Discuss any questions or concerns with your doctor.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking Treanda. Talk with your doctor before you receive any vaccine.
- Tell your doctor or dentist that you take Treanda before you receive any medical or dental care, emergency care, or surgery.
- Use of Treanda may increase your risk of developing another cancer. Discuss any questions or concerns with your doctor.
- Treanda may decrease sperm count in men, which could affect the ability to father a child. Contact your doctor with any questions or concerns.
- Lab tests, including blood electrolyte levels, uric acid levels, complete blood cell counts, or liver and kidney function, may be performed while you use Treanda. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Treanda should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Treanda may cause harm to the fetus. Avoid becoming pregnant while you are using Treanda and for 3 months after you stop Treanda. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Treanda while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Treanda.
Possible side effects of Treanda:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Anxiety; back or join pain; constipation; cough; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; mild fever; mild itching, pain, redness, or swelling at the injection site; mild sore throat; nausea; runny or stuffy nose; stomach pain or upset; swelling or soreness of the mouth or tongue; taste changes; tiredness; trouble sleeping; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; chest, jaw, or arm pain; dark, tarry, or bloody stools; dark urine; decreased urination; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; frequent or painful urination; muscle pain, weakness, or cramping; persistent or severe cough; redness, swelling, peeling, or blistering of the skin; severe or persistent headache or dizziness; severe or persistent heartburn; severe or persistent tiredness or weakness; severe pain, redness, swelling, or sores at the injection site; shortness of breath; sluggishness; sudden, severe nausea or vomiting; swelling of the hands, ankles, or feet; unusual bruising or bleeding; unusual weight changes; very dry mouth or eyes; wheezing; white patches in the mouth.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include irregular heartbeat; loss of coordination; seizures; severe drowsiness; tremor; trouble breathing.Proper storage of Treanda:
Treanda is handled and stored by a health care provider. Keep Treanda out of the reach of children and away from pets.
- If you have any questions about Treanda, please talk with your doctor, pharmacist, or other health care provider.
- Treanda is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Treanda or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Treanda. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Treanda. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Treanda.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Treanda (bendamustine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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- Generic Availability
- Drug class: alkylating agents
Other brands: Bendeka