Generic Name: Tocilizumab (Intravenous) (toe si LIZ oo mab)
Brand Name: Actemra
Medically reviewed on Sep 5, 2018
- Very bad and sometimes deadly infections have happened in patients who take tocilizumab (intravenous). Most people who had these infections were taking other drugs to lower the immune system like methotrexate or steroid drugs. If you have any infection, are taking antibiotics now or in the recent past, or have had many infections, talk with your doctor.
- TB (tuberculosis) has been seen in patients started on tocilizumab (intravenous). These patients were exposed to TB in the past, but never got the infection. You will be tested to see if you have been exposed to TB before starting tocilizumab (intravenous).
Uses of Tocilizumab:
- It is used to treat rheumatoid arthritis.
- It is used to treat juvenile arthritis.
- It is used to treat cytokine release syndrome (CRS).
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Tocilizumab?
- If you have an allergy to tocilizumab or any other part of tocilizumab (intravenous).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have liver disease or raised liver enzymes.
- If you have an infection.
- If you are taking any of these drugs: Abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, or rituximab.
This is not a list of all drugs or health problems that interact with tocilizumab (intravenous).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take tocilizumab (intravenous) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Tocilizumab?
- Tell all of your health care providers that you take tocilizumab (intravenous). This includes your doctors, nurses, pharmacists, and dentists.
- Very bad and sometimes deadly allergic side effects have rarely happened. Talk with your doctor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- If you have high blood sugar (diabetes), talk with your doctor. You may be more likely to get infections.
- If you have had hepatitis B before or carry the virus, talk with your doctor. This medicine can cause the virus to become active again.
- Hepatitis B testing needs to be done as you were told by the doctor. Talk with the doctor.
- This medicine may add to the chance of getting some types of cancer. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Make sure you are up to date with all your vaccines before treatment with tocilizumab (intravenous).
- Talk with your doctor before getting any vaccines. Use with tocilizumab (intravenous) may either raise the chance of an infection or make the vaccine not work as well.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- Treatment with tocilizumab (intravenous) may lead to higher cholesterol and triglycerides. The effect of these changes on heart health is not known. Talk with the doctor.
- This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking tocilizumab (intravenous) with your other drugs.
- Some people have unsafe allergic effects or bad side effects during the infusion or within 24 hours of the infusion. Talk with the doctor.
- If your weight changes, talk with your doctor. The dose of tocilizumab (intravenous) may need to be changed.
- If you are 65 or older, use tocilizumab (intravenous) with care. You could have more side effects.
- Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking tocilizumab (intravenous).
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using tocilizumab (intravenous) while you are pregnant.
- If you used tocilizumab (intravenous) when you were pregnant, tell your baby's doctor.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Tocilizumab) best taken?
Use tocilizumab (intravenous) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight.
- Signs of nervous system problems like change in mood or actions, feeling confused, fever, numbness or tingling in the hands or feet, stiff neck, bright lights bother your eyes, or very bad muscle weakness.
- A skin lump or growth.
- Change in color or size of a mole.
- Shortness of breath.
- Chest pain or pressure.
- Very upset stomach or throwing up.
- Change in bowel habits.
- Tears in the stomach or bowel wall have happened in certain people taking tocilizumab (intravenous). Call your doctor right away if you have swelling or pain in your stomach that is very bad, gets worse, or does not go away. Call your doctor right away if you throw up blood or have throw up that looks like coffee grounds; upset stomach or throwing up that does not go away; or black, tarry, or bloody stools.
What are some other side effects of Tocilizumab?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Signs of a common cold.
- Nose and throat irritation.
- Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
How do I store and/or throw out Tocilizumab?
- If you need to store tocilizumab (intravenous) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time tocilizumab (intravenous) is refilled. If you have any questions about tocilizumab (intravenous), please talk with the doctor, pharmacist, or other health care provider.
More about tocilizumab
- Tocilizumab Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 24 Reviews
- Drug class: interleukin inhibitors
Other brands: Actemra