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Tafenoquine (Malaria Prevention)

Generic Name: Tafenoquine (Malaria Prevention) (ta FEN oh kwin)
Brand Name: Arakoda

Medically reviewed by Drugs.com. Last updated on Mar 28, 2019.

Uses of Tafenoquine:

What do I need to tell my doctor BEFORE I take Tafenoquine?

  • If you have an allergy to tafenoquine (malaria prevention) or any part of tafenoquine (malaria prevention).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have glucose-6-phosphate dehydrogenase (G6PD) deficiency or you have not been tested for it.
  • If you have ever had any mental health or behavior problems.
  • If you are taking any of these drugs: Dofetilide or metformin.
  • If you are pregnant or may be pregnant. Do not take tafenoquine (malaria prevention) if you are pregnant.
  • If you are breast-feeding and your child has G6PD deficiency or your child has not been tested for it. Do not breast-feed for 3 months after taking tafenoquine (malaria prevention) if your child has G6PD deficiency or has not been tested for it.

This is not a list of all drugs or health problems that interact with tafenoquine (malaria prevention).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take tafenoquine (malaria prevention) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Tafenoquine?

  • Tell all of your health care providers that you take tafenoquine (malaria prevention). This includes your doctors, nurses, pharmacists, and dentists.
  • People with an enzyme deficiency called G6PD deficiency may have more chance of getting hemolysis. Do not take tafenoquine (malaria prevention) if you have G6PD deficiency. You may need to be screened for G6PD deficiency before taking tafenoquine (malaria prevention). Talk with your doctor.
  • Other measures are needed along with tafenoquine (malaria prevention) including using screens, bed netting, insect repellent (10% to 35% DEET), and permethrin spray on clothing and nets. Avoid spraying most insect repellents on children. Lower evening and night-time outdoor activity.
  • If you have a fever after leaving a malaria area, call your doctor right away.
  • This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start tafenoquine (malaria prevention) to show that you are NOT pregnant.
  • Women must use birth control while taking tafenoquine (malaria prevention) and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Tafenoquine) best taken?

Use tafenoquine (malaria prevention) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take tafenoquine (malaria prevention) with food.
  • Swallow whole. Do not chew, break, or crush.
  • If using to prevent malaria, start tafenoquine (malaria prevention) before traveling to the high risk place.
  • It is important that you do not miss or skip a dose of tafenoquine (malaria prevention) during treatment.

What do I do if I miss a dose?

  • If a dose is missed, check the package insert or call the doctor or pharmacist to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of hemolytic anemia like dark lips or urine, dizziness or passing out, feeling confused, feeling very tired or weak, pale skin, shortness of breath, or yellow skin or eyes.
  • Signs of methemoglobinemia like a blue or gray color of the lips, nails, or skin; a heartbeat that does not feel normal; seizures; very bad dizziness or passing out; very bad headache; feeling very sleepy; feeling tired or weak; or shortness of breath. This effect is rare but may be deadly if it happens.
  • Mental, mood, or behavior changes that are new or worse.
  • Strange or odd dreams.
  • Trouble sleeping.
  • Hallucinations (seeing or hearing things that are not there).
  • Feeling confused.
  • Very bad dizziness or passing out.

What are some other side effects of Tafenoquine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Tafenoquine?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time tafenoquine (malaria prevention) is refilled. If you have any questions about tafenoquine (malaria prevention), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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