Generic Name: tafenoquine (ta FEN o kwin)
Brand Names: Arakoda
Medically reviewed by Philip Thornton, DipPharm. Last updated on May 28, 2020.
What is Arakoda?
Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.
Arakoda is used to treat malaria in people who are also using other anti-malaria medications.
Arakoda is for use in people 18 years of age and older. It is not known if Arakoda is safe and effective in children.
You should not use Arakoda if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Your doctor will perform a test to make sure you do not have this condition.
Do not take Arakoda if you have a history of psychotic disorders, or you currently have psychotic symptoms including hallucinations (seeing or hearing things that are not really there), delusions (false or strange thoughts or beliefs), or disorganized thinking or behavior.
Before taking this medicine
To make sure Arakoda is safe for you, tell your doctor if:
you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency; or
you are allergic to Arakoda or similar medicines (such as primaquine).
Do not breast-feed while using Arakoda, if your baby has G6PD deficiency (or has not been tested for it). If the baby does have G6PD deficiency, you should also not breast-feed for at least 3 months after your last dose of Arakoda.
You may need to have a negative pregnancy test before starting this treatment.
Do not use Arakoda if you are pregnant. Tafenoquine could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using Arakoda and for at least 3 months after your last dose.
Tell your doctor right away if you become pregnant.
Tell your doctor if you have ever had:
a mental illness; or
liver or kidney disease.
Arakoda is not approved for use by anyone younger than 16 years old.
How should I take Arakoda?
Before you take Arakoda, your doctor will perform a test to make sure you do not have G6PD deficiency.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Start taking Arakoda on the first or second day you start your other anti-malaria medication.
Take with food.
Swallow the tablet whole and do not crush, chew, or break the tablet.
If you vomit within 1 hour after taking Arakoda, call your doctor to ask if you should take another dose or wait until your next scheduled dose time.
Use protective clothing, insect repellents, and mosquito netting around your bed to further prevent mosquito bites that could cause malaria.
No medication is 100% effective in treating or preventing all types of malaria. For best results, keep using the medication as directed.
Store Arakoda tablets at room temperature away from moisture and heat.
Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
Arakoda dosing information
Usual Adult Dose of Arakoda for Malaria:
300 mg orally once as a single dose.
Usual Adult Dose for Malaria Prophylaxis:
Loading dose: 200 mg orally once a day for 3 days
Maintenance dose: 200 mg orally once a week
Terminal prophylaxis dose: 200 mg orally once as a single dose
Duration of therapy: Up to 6 months of continuous dosing
-The loading dose should be administered for each of the 3 days prior to travel to malarious area.
-The maintenance dose should be started 7 days after the last loading dose and should be continued while in the malarious area.
-The terminal prophylaxis regimen should be administered 7 days after the last maintenance dose in the week after exit from malarious area.
-The full course of therapy should be completed (including the loading dose, maintenance dose, and terminal dose).
-To replace missed dose(s):
---If 1 loading dose is missed: 1 dose of 200 mg so that a total of 3 daily loading doses have been administered; the maintenance dose should be started 1 week after the last loading dose
---If 2 loading doses are missed: 2 doses of 200 mg on 2 consecutive days so that a total of 3 daily loading doses have been administered; the maintenance dose should be started 1 week after the last loading dose
---If 1 maintenance (weekly) dose is missed: 1 dose of 200 mg on any day up to the time of the next scheduled weekly dose
---If 2 maintenance (weekly) doses are missed: 1 dose of 200 mg on any day up to the time of the next scheduled weekly dose
---If at least 3 maintenance (weekly) doses are missed: 2 doses of 200 mg, administered as 200 mg once a day for 2 days up to the time of the next scheduled weekly dose
---If the terminal prophylaxis dose is missed: 1 dose of 200 mg as soon as remembered.
Usual Pediatric Dose of Arakoda for Malaria:
16 years or older: 300 mg orally once as a single dose
-This drug is not indicated for the treatment of acute P vivax malaria.
-This drug should be coadministered on the first or second day of appropriate antimalarial therapy for acute P vivax malaria (e.g., chloroquine).
-A repeat dose is recommended if vomiting occurs within 1 hour after dosing; re-dosing should not be attempted more than once.
Use: For the radical cure (prevention of relapse) of P vivax malaria in patients receiving appropriate antimalarial therapy for acute P vivax infection
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Arakoda?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Arakoda side effects
Call your doctor at once if you have:
pale or yellowed skin, dark colored urine;
darkening of your mouth, lips, or fingernails;
feeling light-headed or short of breath;
confusion, tiredness; or
new or worsening mental health problems - anxiety, strange dreams, trouble sleeping.
Common Arakoda side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Arakoda?
Other drugs may interact with tafenoquine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Arakoda only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2020 Cerner Multum, Inc. Version: 1.02.
- What is the difference between Arakoda and Krintafel?
- How do you take Arakoda for the prevention of malaria?
- How do you take Krintafel?
More about Arakoda (tafenoquine)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Imprints, Shape & Color Data
- Drug Interactions
- Pricing & Coupons
- En Español
- 1 Review
- Drug class: antimalarial quinolines
- FDA Approval History
Other brands: Krintafel