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Siltuximab

Generic Name: siltuximab (sil-TUX-i-mab)
Brand Name: Sylvant

Siltuximab is used for:

Treating multicentric Castleman disease (MCD) in certain patients.

Siltuximab is a monoclonal antibody. It works by binding to human interleukin-6.

Do NOT use siltuximab if:

  • you are allergic to any ingredient in siltuximab
  • you have an active, severe infection

Contact your doctor or health care provider right away if any of these apply to you.

Before using siltuximab:

Some medical conditions may interact with siltuximab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an infection, kidney problems, liver problems, HIV, or a certain herpes infection (human herpesvirus-8 [HHV-8])
  • if you have had a recent vaccine or you are scheduled to receive a vaccine
  • if you have or have had stomach or bowel problems (eg, diverticulitis, ulcers)

Some MEDICINES MAY INTERACT with siltuximab. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Atorvastatin, cyclosporine, lovastatin, oral contraceptives (birth control pills), theophylline, or warfarin because their effectiveness may be decreased by siltuximab

This may not be a complete list of all interactions that may occur. Ask your health care provider if siltuximab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use siltuximab:

Use siltuximab as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with siltuximab. Talk to your pharmacist if you have questions about this information.
  • Siltuximab is given as an injection at your doctor's office, hospital, or clinic.
  • Your doctor may give you certain other medicines (eg, acetaminophen; antihistamines, such as diphenhydramine; corticosteroids, such as dexamethasone) before you receive siltuximab.
  • If you miss a dose of siltuximab, contact your doctor right away.

Ask your health care provider any questions you may have about how to use siltuximab.

Important safety information:

  • Tell your doctor or dentist that you take siltuximab before you receive any medical or dental care, emergency care, or surgery.
  • Siltuximab may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking siltuximab. Talk with your doctor before you receive any vaccine.
  • Holes in the gastrointestinal (GI) tract have happened with siltuximab. Discuss any questions or concerns with your doctor.
  • Lab tests may be performed while you use siltuximab. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • If you are able to become pregnant, you must use an effective form of birth control while you take siltuximab and for at least 3 months after you stop taking it. If you have questions about effective birth control, talk with your doctor.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using siltuximab. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • PREGNANCY and BREAST-FEEDING: It is not known if siltuximab can cause harm to the fetus. Do not become pregnant while you are using it or for 3 months after your last dose. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using siltuximab while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking siltuximab.

Possible side effects of siltuximab:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; headache; mouth or throat pain; stomach pain; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); fainting; severe or persistent dizziness or light-headedness; severe or persistent stomach pain, diarrhea, vomiting, or constipation; swelling; symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath); trouble passing urine; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of siltuximab:

Siltuximab is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

General information:

  • If you have any questions about siltuximab, please talk with your doctor, pharmacist, or other health care provider.
  • Siltuximab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take siltuximab or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about siltuximab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to siltuximab. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using siltuximab.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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