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Siltuximab use while Breastfeeding

Drugs containing Siltuximab: Sylvant

Medically reviewed by Drugs.com. Last updated on Jan 26, 2021.

Siltuximab Levels and Effects while Breastfeeding

Summary of Use during Lactation

No information is available on the clinical use of siltuximab during breastfeeding. Because siltuximab is a large protein molecule with a molecular weight of about 145,000 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. Until more data become available, siltuximab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be discontinued during siltuximab therapy and for 3 months after the last dose.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Substance Identification

Substance Name

Siltuximab

CAS Registry Number

541502-14-1

Drug Class

Breast Feeding

Lactation

Antibodies, Monoclonal

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Further information

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