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Siltuximab Dosage

Medically reviewed by Last updated on Feb 27, 2024.

Applies to the following strengths: 100 mg; 400 mg

Usual Adult Dose for Castleman's Disease

11 mg/kg IV over 1 hour every 3 weeks until treatment failure

Treatment Criteria:


Use: For the treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

Renal Dose Adjustments

Mild to severe renal impairment (CrCl 15 mL/min to under 90 mL/min): No adjustment recommended.
End stage renal disease (CrCl less than 15 mL/min): Data not available

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Data not available



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration Advice:

Storage requirements:

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.