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Generic name: satralizumabSAT-ra-LIZ-ue-mab ]
Drug class: Interleukin inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Nov 14, 2023.

What is Enspryng?

Enspryng is a recombinant humanized monoclonal antibody targeting human interleukin-6 (IL-6) receptors.

Enspryng is a prescription medicine used to treat adults with neuromyelitis optica spectrum disorder (NMOSD). NMOSD is a rare, chronic autoimmune disease that causes inflammation in the central nervous system. This can lead to damage of the optic nerves, spinal cord, and/or brain.

Enspryng is used only if your body produces antibodies to a protein called aquaporin-4 (AQP4). Your doctor will test you for this antibody.


Enspryng affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have signs of infection (fever, chills, cough, tiredness, muscle pain, diarrhea, stomach cramps, increased urination, burning when you urinate, skin sores or redness, swelling or tenderness).

Your healthcare provider will check if you have an infection and treat it if needed before you start or continue to take Enspryng.

Your healthcare provider should test you for hepatitis and tuberculosis (TB) before you start taking Enspryng.

Before taking this medicine

You should not use Enspryng if you are allergic to satralizumab, or if you have an active infection such as:

To make sure Enspryng is safe for you, tell your doctor if you have ever had: tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.

To make sure Enspryng is safe for you, tell your doctor if you have ever had::

Make sure you are current on all vaccines before you begin treatment with Enspryng.

You should not receive a "live" vaccine for at least 4 weeks before using Enspryng. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

You should not receive a "non-live" (sometimes called inactivated) vaccine for at least 2 weeks before using Enspryng. Non-live vaccines include the flu (influenza) shot and injected vaccines for hepatitis A, polio, or rabies.

Tell your doctor if you are pregnant or breastfeeding.

If you use Enspryng while you are pregnant, make sure any doctor caring for your new baby knows that you used this medicine during pregnancy. Being exposed to satralizumab in the womb could affect your baby's vaccination schedule.

How should I use Enspryng?

Use Enspryng exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Your doctor may perform tests to make sure you do not have conditions that would prevent you from safely using Enspryng.

Enspryng is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Prepare an injection only when you are ready to give it. Do not shake the prefilled syringe. Do not use if the syringe is damaged or if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Enspryng is given in 3 loading doses once every 2 weeks, followed by maintenance doses given once every 4 weeks. Your doctor will determine how long to treat you with this medicine.

Inject all of the medicine in the prefilled syringe. Tell your doctor if you don't receive the full dose.

Your healthcare provider will show you where on your body to inject Enspryng. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

You will need frequent medical tests.

Call your doctor if you have any signs of infection (fever, chills, cough, sore throat). Do not inject this medicine while you are having signs of an active infection.

If you stop using Enspryng for a short time, you may need to restart the medicine using loading doses once every 2 weeks. Follow your doctor's instructions very carefully.

Store in the refrigerator. Protect from light and do not freeze.

Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before injecting your dose. Do not leave the medicine out of a refrigerator for longer than 8 days. Do not warm the medicine, and protect it from high heat.

Each prefilled syringe is for one use only. Throw it away after one use, even if there is still medicine left inside.

Dosing information

Usual Adult Dose for Neuromyelitis Optica:

120 mg subcutaneously at Weeks 0, 2, and 4, followed by 120 mg subcutaneously every 4 weeks

Use: For the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

If you have stopped treatment for a side effect or infection, carefully follow your doctor's instructions about the schedule for restarting the medicine.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Do not inject this medicine into scars, moles, broken skin, or skin that is red, bruised, tender, or hard.

Do not receive any vaccine while using Enspryng.

Enspryng side effects

Stop using this medicine and get emergency medical help if you have signs of an allergic reaction to Enspryng: hives; feeling light-headed; stomach pain, vomiting; difficult breathing; swelling of your face, lips, tongue, or throat.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

Common Enspryng side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Enspryng?

Other drugs may interact with satralizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

Enspryng is given as an injection under the skin (a subcutaneous injection) in the thigh or stomach area to treat neuromyelitis optica spectrum disorder (NMOSD) in adults. Your healthcare provider can teach you how to give these injections at home. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Enspryng only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.