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Enspryng Side Effects

Generic name: satralizumab

Medically reviewed by Last updated on Apr 17, 2021.

Note: This document contains side effect information about satralizumab. Some of the dosage forms listed on this page may not apply to the brand name Enspryng.

For the Consumer

Applies to satralizumab: subcutaneous solution

Side effects requiring immediate medical attention

Along with its needed effects, satralizumab (the active ingredient contained in Enspryng) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking satralizumab:

More common

  • Black, tarry stools
  • body aches or pain
  • burning feeling in the chest or stomach
  • chills
  • cough
  • dark urine
  • depression
  • difficulty in moving
  • dryness or soreness of the throat
  • ear congestion
  • falls
  • fever
  • headache
  • hoarseness
  • indigestion
  • joint pain
  • light-colored stools
  • loss of voice
  • lower back or side pain
  • muscle pain or stiffness
  • nausea and vomiting
  • painful or difficult urination
  • pain, redness, swelling, tenderness, or warmth on the skin
  • pale skin
  • skin rash, hives, itching
  • sneezing
  • sore throat
  • stomach upset
  • stuffy or runny nose
  • tenderness in the stomach area
  • tender, swollen glands in the neck
  • trouble breathing or swallowing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right stomach pain
  • weight gain
  • yellow eyes and skin

Side effects not requiring immediate medical attention

Some side effects of satralizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to satralizumab: subcutaneous solution


Very common (10% or more): Neutropenia (10%), blood creatine phosphokinase[Ref]


Very common (10% or more): Cellulitis (10%)

Frequency not reported: Potential for immunogenicity[Ref]


Frequency not reported: Injection site reaction, skin mass[Ref]


Very common (10% or more): Arthralgia (17%), pain in extremity (15%)[Ref]


Very common (10% or more): Weight gain (30%), cholesterol increased (15%)[Ref]


Very common (10% or more): Depression (10%)[Ref]


Very common (10% or more): Fibrinogen levels increased (38%), ALT and AST elevated (43%)[Ref]


Very common (10% or more): Nasopharyngitis (31%), upper respiratory tract infection (19%), pharyngitis (12%)[Ref]


Very common (10% or more): Fatigue (15%), fall (10%)[Ref]


The most common adverse reactions (15% or greater) were nasopharyngitis, headache, upper respiratory tract infection, gastritis, rash, arthralgia, extremity pain, fatigue, and nausea.[Ref]

Nervous system

Very common (10% or more): Headache (27%)[Ref]


Very common (10% or more): Rash (17%), pruritus (12%)[Ref]


Very common (10% or more): Gastritis (15%), nausea (15%)[Ref]


1. "Product Information. Enspryng (satralizumab)." Genentech, South San Francisco, CA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.