Generic Name: Darunavir and Cobicistat (dar OO na veer & koe BIK i stat)
Brand Name: Prezcobix
Medically reviewed by Drugs.com. Last updated on Sep 18, 2020.
Uses of Prezcobix:
- It is used to treat HIV infection.
What do I need to tell my doctor BEFORE I take Prezcobix?
- If you are allergic to Prezcobix (darunavir and cobicistat); any part of Prezcobix (darunavir and cobicistat); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have liver disease.
- If you are taking another drug that has the same drug in it.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Prezcobix (darunavir and cobicistat), like certain drugs that are used for high cholesterol, migraines, or mood problems. There are many drugs that must not be taken with Prezcobix (darunavir and cobicistat).
- If you are taking St. John's wort. Do not take St. John's wort with Prezcobix (darunavir and cobicistat). This medicine may not work as well.
- If you are also taking tenofovir and you have kidney problems or take a drug that may harm the kidneys.
- If you are pregnant or may be pregnant. Do not take Prezcobix (darunavir and cobicistat) if you are pregnant.
- If you are breast-feeding. Do not breast-feed while you take Prezcobix (darunavir and cobicistat).
This is not a list of all drugs or health problems that interact with Prezcobix (darunavir and cobicistat).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Prezcobix (darunavir and cobicistat) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Prezcobix?
- Tell all of your health care providers that you take Prezcobix (darunavir and cobicistat). This includes your doctors, nurses, pharmacists, and dentists.
- If you have a sulfa (sulfonamide) allergy, talk with your doctor.
- This medicine interacts with many other drugs. The chance of Prezcobix (darunavir and cobicistat)'s side effects may be raised or how well Prezcobix (darunavir and cobicistat) works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take Prezcobix (darunavir and cobicistat) with all of your other drugs (prescription or OTC, natural products, vitamins).
- High blood sugar has happened with Prezcobix (darunavir and cobicistat). This includes diabetes that is new or worse.
- Check your blood sugar as you have been told by your doctor.
- Some people with hemophilia have had times of more bleeding when taking drugs like this one. If you have hemophilia, talk with your doctor.
- Very bad kidney problems like kidney failure have happened in people taking cobicistat with tenofovir.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine is not a cure for HIV. Stay under the care of your doctor.
- This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors.
- Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking Prezcobix (darunavir and cobicistat).
How is this medicine (Prezcobix) best taken?
Use Prezcobix (darunavir and cobicistat) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take Prezcobix (darunavir and cobicistat) with food.
- Take Prezcobix (darunavir and cobicistat) at the same time of day.
- Keep taking Prezcobix (darunavir and cobicistat) as you have been told by your doctor or other health care provider, even if you feel well.
- It is important that you do not miss or skip a dose of Prezcobix (darunavir and cobicistat) during treatment.
- If you are also taking didanosine, take it at least 1 hour before or 2 hours after Prezcobix (darunavir and cobicistat).
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it, with food.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do if you miss a dose, call your doctor.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Feeling very tired or weak.
- Change in body fat.
- Muscle or joint pain.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Changes in your immune system can happen when you start taking drugs to treat HIV. If you have an infection that you did not know you had, it may show up when you take Prezcobix (darunavir and cobicistat). Tell your doctor right away if you have any new signs after you start Prezcobix (darunavir and cobicistat), even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.
- Liver problems have rarely happened with Prezcobix (darunavir and cobicistat). Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Prezcobix?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
How do I store and/or throw out Prezcobix?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Prezcobix (darunavir and cobicistat), please talk with your doctor, nurse, pharmacist, or other health care provider.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Frequently Asked Questions
More about Prezcobix (cobicistat / darunavir)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 3 Reviews
- Drug class: antiviral combinations
- FDA Approval History